Simplifying clinical risk prediction for percutaneous coronary intervention of bifurcation lesions: the case for the ACEF (age, creatinine, ejection fraction) score

EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Giuseppe Biondi-ZoccaiGiuseppe Sangiorgi

Abstract

We aimed to appraise the predictive accuracy of a novel and user-friendly risk score, the ACEF (age, creatinine, ejection fraction), in patients undergoing PCI for coronary bifurcations. A multicentre, retrospective study was conducted enrolling consecutive patients undergoing bifurcation PCI between January 2002 and December 2006 in 22 Italian centres. Patients with complete data to enable computation of the ACEF score were divided into three groups according to tertiles of ACEF score. The primary endpoint was 30-day mortality. The discrimination of the ACEF score as a continuous variable was also appraised with area under the curve (AUC) of the receiver-operating characteristic. A total of 3,535 patients were included: 1,119 in the lowest tertile of ACEF score, 1,190 in the mid tertile, and 1,153 in the highest tertile. Increased ACEF score was associated with significantly different rates of 30-day mortality (0.1% in the lowest tertile vs. 0.5% in the mid tertile and 3.0% in the highest tertile, p<0.001), with similar differences in myocardial infarction (0.3% vs. 0.7% and 1.8%, p<0.001) and major adverse cardiac events (MACE, 0.5% vs. 1.2% and 4.3%, p<0.001). After an average follow-up of 24.4±15.1 months, increased ACEF sc...Continue Reading

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Citations

Jul 24, 2013·Journal of Cardiovascular Medicine·Fabrizio D'AscenzoFiorenzo Gaita
May 8, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Takahide AraiMarie-Claude Morice
Aug 12, 2014·Journal of Cardiovascular Medicine·Claudio MorettiFiorenzo Gaita
Dec 27, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Guofeng GaoKefei Dou
Nov 1, 2015·European Heart Journal. Quality of Care & Clinical Outcomes·Claudio MorettiFiorenzo Gaita
Jan 12, 2021·Journal of Interventional Cardiology·Yong-Ming HeJun-Bo Ge

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