Simplifying Skin Disease Diagnosis with Topical Nanotechnology

SLAS Technology
David C Yeo, Chenjie Xu

Abstract

A new study published in the journal Nature Biomedical Engineering1 documents a novel diagnostic technology that exploits topically applied nanotechnology to detect skin tissue biomarkers for diagnosis. This concept is demonstrated by noninvasively imaging connective tissue growth factor (CTGF) mRNA in abnormal scar cells, whole tissue, and animal models. In this commentary, we highlight the main findings and discuss their implications. Successful implementation in the clinic could give rise to self-applied, biopsy-free diagnostic technology and significantly reduce healthcare burden. Crucially, noninvasive visualization of disease biomarkers, mobile device signal acquisition, and Internet-enabled transmission could significantly transform the diagnosis of skin disease and other superficial tissues.

References

Jul 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Dan ZhengAmy S Paller
Nov 19, 2014·Proceedings of the National Academy of Sciences of the United States of America·Tiffany L HaloC Shad Thaxton
Sep 20, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Michael ZakrewskySamir Mitragotri
Jan 10, 2018·Angewandte Chemie·Qingqing MiaoKanyi Pu

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

NanoFlare
NanoFlares

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