Simpson Grade I-III Resection of Spinal Atypical (World Health Organization Grade II) Meningiomas is Associated With Symptom Resolution and Low Recurrence

Neurosurgery
Sam Q SunWilson Z Ray

Abstract

Because of their rarity, outcomes regarding spinal atypical meningiomas (AMs) remain unclear. To describe the recurrence rate and postoperative outcomes after resection of spinal AMs, and to discuss an appropriate resection strategy and adjuvant therapy for spinal AMs. Data from all patients who presented with spinal AMs to 2 tertiary referral centers between 1998 and 2013 were obtained by chart review. From 102 patients with spinal meningioma, 20 AM tumors (7 cervical, 11 thoracic, 2 thoracolumbar) were identified in 18 patients (median age, 50 years [range, 19-75] at time of resection; 11% male; median follow-up, 32 months [range, 1-179] after resection). Before resection, patients had sensory deficits (70%), pain (70%), weakness (60%), ataxia (50%), spasticity (65%), and incontinence (35%). One tumor presented asymptomatically. Simpson grade I, II, III, and IV resection were achieved in 3 (15%), 13 (65%), 2 (10%), and 2 (10%) tumors, respectively. One patient that underwent Simpson grade III resection received adjuvant radiation therapy. After Simpson grade I-III or gross total resection, no tumors recurred (0%; confidence interval, 0%-17.6%). After Simpson grade IV resection, 1 tumor recurred (50%; confidence interval, 1.3%...Continue Reading

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Citations

Mar 26, 2016·Neurosurgery Clinics of North America·Vijay M Ravindra, Meic H Schmidt
Jun 25, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Iddo PaldorYigal Shoshan
Sep 26, 2020·Frontiers in Oncology·Lianhua ZhaoZaiyu Guo

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