PMID: 11604165Oct 18, 2001Paper

Simulated solar UVB exposure inhibits transcutaneous immunization to cholera toxin via an irradiated skin site in cattle

Veterinary Immunology and Immunopathology
C K MorrowR B Cope

Abstract

Transcutaneous immunization (TCI) is a new needle-free vaccination technology with the potential to reduce the risk of needle-borne disease transmission and carcass damage within the livestock industries. The principal antigen-presenting cell involved in TCI is thought to be the epidermal Langerhans cell. Langerhans cell function is inhibited by cutaneous ultraviolet-B radiation (UVB) exposure. Such exposure may inhibit TCI through sun exposed skin sites due to the phenomenon of local low dose photoimmunosuppression. TCI of cattle to cholera toxin (CT) resulted in the generation of a serum anti-CT-specific IgG(2) response. However, exposure of cattle to a sub-inflammatory dose of simulated solar UVB (2.43 x 10(3)J/m(2)) significantly (P<0.05) inhibited TCI to CT via irradiated skin sites.

References

Mar 29, 2000·Australian Veterinary Journal·R B Cope, I G Colditz
Aug 12, 2000·Redox Report : Communications in Free Radical Research·G W DandieH K Muller
Sep 1, 2000·Advanced Drug Delivery Reviews·S A HammondG M Glenn
Sep 16, 2000·Photochemistry and Photobiology·D B BrownF P Gasparro
Jan 4, 2001·Veterinary Immunology and Immunopathology·D ChenC G Tsonis
Feb 13, 2001·Immunology and Cell Biology·G W DandieH K Muller
Jul 5, 2005·Expert Opinion on Investigational Drugs·G M GlennC R Alving

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