Simulated transport alters surfactant homeostasis and causes dose-dependent changes in respiratory function in neonatal Sprague-Dawley rats.

Journal of Perinatal Medicine
Shetal ShahAvinash Chander

Abstract

Forces transmitted to the neonate as a consequence of accelerations during transport have been associated with adverse neonatal outcomes including broncho-pulmonary dysplasia. In this study, we sought to determine the relationship between the duration of transport and respiratory performance in the rat model. Four groups of Sprague-Dawley rat pups (10-12 pups/groups) were exposed to simulated medical transport on postnatal day of life 11 or 12. Each group was exposed to an average impulse of 27.4 m/s(2)/min for 0, 30, 60 or 90 min. During the exposure periods, impulse was monitored by computerized sampling using a digital accelerometer. Post-exposure, animals were immediately prepared, placed on mechanical ventilation and analyzed for elastance, tissue damping, airway resistance, ratio of damping to elastance (eta), hysteresivity, and inertance at positive end expiratory pressures (PEEPs) of 0, 3 and 6 cm(3) of H(2)O. Total phospholipid content and surfactant proteins A, B, and C mRNA levels in broncho-alveolar lavage fluid and lung tissue were obtained. Increased transport time resulted in a significant step-wise increase in airway resistance at all levels of PEEP (P<0.01). Static compliance decreased significantly after 60 mi...Continue Reading

References

Mar 1, 1992·American Journal of Perinatology·B A Yoder
Oct 1, 1981·The Journal of Pediatrics·C E ClarkR A Ballard
Jul 1, 1994·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·H B SherwoodJ Giebe
May 1, 1996·Journal of Applied Physiology·K R LutchenB Suki
Jul 1, 1997·American Journal of Obstetrics and Gynecology·J HittiD A Eschenbach
Feb 26, 1998·American Journal of Respiratory and Critical Care Medicine·M J HaydenP D Sly
May 30, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·F GhezziM Mazor
Jun 10, 1998·Journal of Child Neurology·R D Sheth, M E Jaynes
Jun 30, 2000·Journal of Perinatal Medicine·M GleissnerS Avenarius
Aug 2, 2000·Journal of Perinatology : Official Journal of the California Perinatal Association·G GajendragadkarJ P Shenai
Nov 25, 2000·Journal of Applied Physiology·J A AdamsM A Sackner
Nov 25, 2000·Journal of Applied Physiology·J A AdamsM A Sackner
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·A H Jobe, E Bancalari
Aug 30, 2001·Pediatric Cardiology·L Hellström-WestasN Svenningsen
Oct 6, 2001·Critical Care Medicine·J A AdamsM A Sackner
Nov 24, 2001·Resuscitation·J A AdamsM A Sackner
Jun 19, 2002·Journal of Applied Physiology·Shinichiro TomiokaCharles G Irvin
Apr 2, 2003·Seminars in Neonatology : SN·Alan H Jobe
Feb 26, 2004·Paediatric Respiratory Reviews·Neil N Finer
Jun 26, 2004·Biology of the Neonate·Sam Hawgood
Aug 16, 2006·Experimental Lung Research·David BroussardLennart K A Lundblad

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Citations

Jan 7, 2017·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Laurence BlaxterDon Sharkey
Jul 2, 2019·NeoReviews·Gillian BrennanChristine Carlos

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