Simulating T-cell motility in the lymph node paracortex with a packed lattice geometry.

Immunology and Cell Biology
Gib Bogle, P Rod Dunbar

Abstract

Agent-based simulation modelling of T-cell trafficking, activation and proliferation in the lymph node paracortex requires a model for cell motility. Such a model must be able to reproduce the observed random-walk behaviour of T cells, while accommodating large numbers of tightly packed cells, and must be computationally efficient. We report the development of a motility model, based on a three-dimensional lattice geometry, that meets these objectives. Cells make discrete jumps between neighbouring lattice sites in directions that are randomly determined from specified discrete probability distributions, which are defined by a small number of parameters. It is shown that the main characteristics of the random motion of T cells as typically observed in vivo can be reproduced by suitable specification of model parameters. The model is computationally highly efficient and provides a suitable engine for a model capable of simulating the full T-cell population of the paracortex.

References

Jan 1, 1977·The Journal of Experimental Medicine·J B Hay, B B Hobbs
Apr 1, 1976·The Journal of Experimental Medicine·R N CahillZ Trnka
Aug 1, 1988·Scandinavian Journal of Immunology·J WestermannR Pabst
Mar 1, 1972·Cell and Tissue Kinetics·W L Ford, S J Simmonds
Oct 1, 1972·The Journal of Experimental Medicine·P G HermanH Z Mellins
Jun 8, 2002·Science·Sabine StollRonald N Germain
Nov 5, 2002·Nature Reviews. Immunology·Michael D CahalanMark J Miller
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mark J MillerIan Parker
May 6, 2003·Nature Immunology·Philippe Bousso, Ellen Robey
Aug 6, 2003·Current Opinion in Immunology·Michael D CahalanMark J Miller
Sep 13, 2003·Immunological Reviews·Sindy H WeiMichael D Cahalan
Mar 24, 1955·Annals of the New York Academy of Sciences·M MCCUTCHEON
Oct 7, 2003·Archives of Histology and Cytology·Osamu OhtaniBren J Gannon
Jan 9, 2004·Nature·Thorsten R MempelUlrich H Von Andrian
Jan 15, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mark J MillerIan Parker
Sep 11, 2004·Immunity·Cenk SumenUlrich H von Andrian
Sep 24, 2004·The Journal of Experimental Medicine·Tomoya KatakaiAkira Shimizu
Oct 7, 2004·The Journal of Experimental Medicine·Mark J MillerMichael D Cahalan
Nov 2, 2004·Nature Immunology·Stéphanie HuguesSebastian Amigorena
Mar 18, 2005·Annual Review of Immunology·Jason G Cyster
Jun 14, 2005·Biophysical Journal·David SelmecziHenrik Flyvbjerg
Oct 12, 2005·Seminars in Immunology·Ronald N GermainHai Qi
Nov 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kelly A SoderbergAkiko Iwasaki
Mar 22, 2006·Nature Immunology·Michael D Cahalan, George A Gutman
Jul 13, 2006·The Journal of Experimental Medicine·Brian WebsterTheresa T Lu
Oct 28, 2006·Toxicologic Pathology·Cynthia L Willard-Mack
Dec 19, 2006·Immunity·Thorsten R MempelUlrich H von Andrian
Feb 6, 2007·Trends in Immunology·Hugh RosenPedro J Gonzalez-Cabrera
Feb 28, 2007·The Journal of Experimental Medicine·Tim WorbsReinhold Förster

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Citations

Nov 4, 2009·Immunology and Cell Biology·Gib Bogle, P Rod Dunbar
Aug 22, 2009·PLoS Computational Biology·Frederik Graw, Roland R Regoes
Mar 30, 2012·PLoS Computational Biology·Frederik Graw, Roland R Regoes
Nov 21, 2012·PLoS Computational Biology·Renske M A VroomansJoost B Beltman
Nov 19, 2013·PLoS Pathogens·Nafisa-Katrin Seich Al BasatenaBecca Asquith
Dec 23, 2015·Bulletin of Mathematical Biology·Laura J CooperTiina Roose
Jul 30, 2011·Journal of Theoretical Biology·Henry P MirskyDenise E Kirschner
Dec 21, 2012·European Journal of Immunology·Burkhard LudewigGennady Bocharov
Jan 5, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Simeone MarinoDenise E Kirschner
Jul 3, 2013·Journal of Theoretical Biology·Chang GongD Kirschner
Nov 22, 2011·Journal of Theoretical Biology·Graham M Donovan, Grant Lythe
Apr 20, 2016·Immunology and Cell Biology·Hélène D MoreauPhilippe Bousso
Jun 15, 2016·Transplantation Reviews·Gustavo A Vásquez-MontoyaJuan P Hernández-Ortiz
Oct 21, 2016·Bulletin of Mathematical Biology·Raluca EftimieDoreen A Cantrell
Oct 17, 2009·Nature Reviews. Immunology·Joost B BeltmanRob J de Boer
Mar 27, 2015·Briefings in Bioinformatics·Antonio CappuccioFilippo Castiglione
Feb 1, 2019·Processes·Kerri-Ann NortonAleksander S Popel
May 11, 2018·IET Systems Biology·Snehal B Shinde, Manish P Kurhekar
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Gib Bogle, P Rod Dunbar

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