Jun 7, 1987

Simulation analysis of conduction of excitation in the atrioventricular node

Journal of Theoretical Biology
S UrushibaraR Suzuki


The excitation conduction in the atrioventricular node was simulated based on the spatially discrete model of the heart proposed in an earlier paper (Kawato et al., 1986). We constructed a model system composed of the atrium, the atrioventricular node and the Purkinje fiber. Coupling coefficients between these tissues were quantitatively estimated from experimental data on size and membrane capacitance of the three kinds of cardiac cells. We found the following three important features in the simulated excitation conduction along the atrioventricular node. First, shape of action potential was found to be different at different locations of the atrioventricular node although the membrane properties were assumed uniform through the atrioventricular node. Our analysis suggests that the difference in the action potential waveforms observed by Paes de Carvalho & De Almedia (1960) can be ascribed to the electrical influences of the atrium and the His bundle on the atrioventricular node. Second, when the excitation wavefront invaded the atrioventricular node from the atrium, a step was observed in the depolarization phase of the action potential at the atrioventricular node neighboring with the atrium. Janse found a similar step in th...Continue Reading

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Mentioned in this Paper

Structure of Purkinje Fibers
phenyl-2-aminoethyl sulfide
Action Potentials
Electric Conductivity
Atrial Function
Cardiac Conduction System
Structure of Atrioventricular Node
Entire Atrium
Bundle of His

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