Simulation and matching-based approaches for indirect comparison of treatments

PharmacoEconomics
K Jack IshakAgnes Benedict

Abstract

Estimates of the relative effects of competing treatments are rarely available from head-to-head trials. These effects must therefore be derived from indirect comparisons of results from different studies. The feasibility of comparisons relies on the network linking treatments through common comparators; the reliability of these may also be impacted when the studies are heterogeneous or when multiple intermediate comparisons are needed to link two specific treatments of interest. Simulated treatment comparison and matching-adjusted indirect comparison have been developed to address these challenges. These focus on comparisons of outcomes for two specific treatments of interest by using patient-level data for one treatment (the index) and published results for the other treatment (the comparator) from compatible studies, taking into account possible confounding due to population differences. This paper provides an overview of how and when these approaches can be used as an alternative or to complement standard MTC approaches.

References

Feb 10, 1998·Medical Decision Making : an International Journal of the Society for Medical Decision Making·V Hasselblad
Feb 12, 2002·Statistics in Medicine·Hans C van HouwelingenTheo Stijnen
Sep 5, 2002·Statistics in Medicine·Thomas Lumley
Sep 28, 2004·Statistics in Medicine·G Lu, A E Ades
Oct 15, 2005·BMJ : British Medical Journal·Deborah M CaldwellJ P T Higgins
Jun 26, 2007·Statistics in Medicine·Alexander J Sutton, Julian P T Higgins
Sep 14, 2010·PharmacoEconomics·J Jaime Caro, K Jack Ishak
Oct 12, 2011·BMC Medical Research Methodology·Martin W Hoyle, William Henley
Sep 25, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·James E SignorovitchEric Q Wu
May 16, 2013·PharmacoEconomics·K Jack IshakNoemi Muszbek

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Citations

Apr 28, 2016·BMC Medical Research Methodology·Areti Angeliki VeronikiAndrea C Tricco
May 15, 2016·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·D LeeA Briggs
Jan 24, 2019·Arthritis Research & Therapy·Ernest ChoyChiara Perella
Dec 25, 2019·Journal of Comparative Effectiveness Research·Ian ChauPranav Abraham
Sep 24, 2019·Biometrical Journal. Biometrische Zeitschrift·Tanja ProctorMeinhard Kieser
Aug 22, 2017·Medical Decision Making : an International Journal of the Society for Medical Decision Making·David M PhillippoNicky J Welton
Jul 21, 2020·Journal of the Royal Statistical Society. Series A, (Statistics in Society)·David M PhillippoNicky J Welton
Mar 19, 2021·Journal of Comparative Effectiveness Research·Gabriel TremblayJoseph C Cappelleri
Nov 2, 2020·Research Synthesis Methods·Dan JacksonMario Ouwens
Aug 11, 2021·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Venediktos KapetanakisMurtuza Bharmal
Jul 2, 2021·Research Synthesis Methods·Antonio Remiro-AzócarGianluca Baio
Jan 22, 2019·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Helmut PettoMark Belger

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