Simulation and visualization of dose uncertainties due to interfractional organ motion

Physics in Medicine and Biology
D MaleikeU Oelfke

Abstract

In this paper, we deal with the effects of interfractional organ motion during radiation therapy. We consider two problems: first, treatment plan evaluation in the presence of motion, and second, the incorporation of organ motion into IMRT optimization. Concerning treatment plan evaluation, we face the problem that the delivered dose cannot be predicted with certainty at the time of treatment planning but is associated with uncertainties. We present a method to simulate stochastic properties of the dose distribution. This provides the treatment planner with information about motion-related risks of different plans and may support the decision for or against a treatment plan. This information includes the display of probabilities of individual voxels to receive doses from a therapeutical interval or above critical levels, as well as a diagram that shows the variability of the dose volume histogram. Concerning the incorporation of organ motion into IMRT planning, we further analyse the approach of inverse planning based on probability distributions of possible patient geometries. We consider three different sources of uncertainty, namely uncertainty about the amplitude of motion, a systematic error and a random error. We analyse ...Continue Reading

References

Sep 25, 1998·International Journal of Radiation Oncology, Biology, Physics·A TingerC A Perez
Apr 24, 2001·International Journal of Radiation Oncology, Biology, Physics·K M Langen, D T Jones
Jan 31, 2004·Seminars in Radiation Oncology·Thomas BortfeldEike Rietzel
Feb 18, 2005·Physics in Medicine and Biology·J Unkelbach, U Oelfke
Aug 4, 2005·Physics in Medicine and Biology·Kwok L LamStephen M Pollock

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Citations

Jan 18, 2008·Physics in Medicine and Biology·Hualiang ZhongJeffrey V Siebers
Oct 1, 2010·Medical Physics·B SobottaM Alber
Feb 11, 2012·Medical Physics·Wei LiuRadhe Mohan
Jun 2, 2012·International Journal of Radiation Oncology, Biology, Physics·Sebastian HildChristoph Bert
Jun 30, 2010·International Journal of Radiation Oncology, Biology, Physics·Hosang JinSiyong Kim
Apr 25, 2014·IEEE Transactions on Medical Imaging·Andriy FedorovMark G Vangel
May 22, 2013·International Journal of Radiation Oncology, Biology, Physics·Peter C ParkLei Dong
Nov 13, 2018·Physics in Medicine and Biology·Jan UnkelbachHuijun Xu
Nov 18, 2006·Physics in Medicine and Biology·J Unkelbach, U Oelfke
Jul 24, 2013·Physics in Medicine and Biology·Mark BangertUwe Oelfke
Jun 29, 2011·Physics in Medicine and Biology·F AlbertiniA J Lomax
May 27, 2016·Physics in Medicine and Biology·Zoltán PerkóDanny Lathouwers
Sep 11, 2020·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Lamberto WidesottMaurizio Del Greco

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