PMID: 8953553Dec 1, 1996Paper

Simulation of cardiac activity and the ECG using a heart model with a reaction-diffusion action potential

Medical Engineering & Physics
O Berenfeld, S Abboud

Abstract

A computerized model of the heart for the simulation of the electrical cardiac activity is described. The cardiac cells are arranged in a three-dimensional cubic lattice and their action potential is governed by modified FitzHugh-Nagumo reaction-diffusion state equations system which exhibits properties such as oscillations, variable excitability and refractoriness. The modifications of the FitzHugh-Nagumo equations system account for asymmetric action potential regarding the fast depolarization and slow repolarization rate and for rotational anisotropic propagation. An isolated cell is tested for reproduction of the strength-duration curves and restitution. The structure basic unit cell is assigned with an individual set of control parameters that creates inhomogeneity and anisotropy to simulate the various cardiac components such as pacers, muscle cells and conduction fibers. The spatial resolution of the structure is 1 mm. The collective activity of the cells generates a realistic ECG waveform that scales the simulated temporal step unit to 0.2 msec. The effective diffusion coefficient ranges between 0.055 mm2/msec to 1 mm2/msec. The propagation velocity of the myocardial activation is calculated at normal direction to the w...Continue Reading

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Citations

Jul 19, 2006·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Jeffrey L WilliamsSamir Saba
Aug 18, 2004·IEEE Transactions on Bio-medical Engineering·Marie-Claude TrudelL Joshua Leon
Dec 13, 2006·IEEE Transactions on Bio-medical Engineering·Mark PotseRamesh M Gulrajani
Jul 10, 2003·IEEE Transactions on Bio-medical Engineering·Martin L Buist, Andrew J Pullan
Jun 16, 2011·Progress in Biophysics and Molecular Biology·R BordasB Rodriguez
Oct 4, 2007·Progress in Biophysics and Molecular Biology·K H W J Ten Tusscher, A V Panfilov
Nov 9, 2016·PloS One·James CrowcombeEdward Tarte
Jul 23, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Dmitri G LuchinskyPeter V E McClintock
Jul 23, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Andrea DuggentoPeter V E McClintock
Dec 14, 2019·Scientific Reports·M A Quiroz-JuárezR A Barrio

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