PMID: 6403493Feb 1, 1983Paper

Simulation of continuous blood O2 equilibrium curve over physiological pH, DPG, and Pco2 range

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
R M WinslowR I Shrager

Abstract

We analyzed 56 O2 equilibrium curves of fresh human blood, each from 0 to 150 Torr Po2. The data were collected over ranges of values for the 2,3-diphosphoglyceric acid-to-hemoglobin concentration ratio [DPG]/[Hb] of 0.2-2.7, for pH of 7.0-7.8, and for Pco2 of 7-70 Torr. Each curve was characterized according to the Adair scheme for the stepwise oxygenation of Hb, and the resulting constants (a1, a2, a3, a4) were analyzed to allow the simulation of the entire O2 equilibrium curve under any conditions of [DPG]/[Hb], pH, and Pco2 in the specified range. This analysis provides a powerful tool to study the affinity of Hb for O2 within the red blood cell and to predict the shape of the O2 equilibrium curve in various physiological and pathological states. Other attempts to predict blood O2 affinity have considered only P50 (the Po2 at one-half saturation with O2) or have provided too little data for continuous simulations.

Citations

Jan 1, 1985·International Journal of Clinical Monitoring and Computing·R M Winslow
Jan 1, 1985·International Journal of Clinical Monitoring and Computing·M SamajaP Cerretelli
Jun 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Amy G TsaiMarcos Intaglietta
Jun 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Amy G TsaiRobert M Winslow
Feb 18, 2010·Annals of Biomedical Engineering·Ranjan K Dash, James B Bassingthwaighte
Jan 20, 2019·Annals of Biomedical Engineering·Robert A ZimmermanDaniel M Tartakovsky
Apr 6, 2007·Journal of Biomechanical Engineering·Jennifer R ZierenbergJames B Grotberg
Feb 1, 1986·Acta Physiologica Scandinavica·J GrønlundA M Carter
Feb 3, 2005·Annals of Biomedical Engineering·Ranjan K Dash, James B Bassingthwaighte
Aug 15, 2020·International Journal for Numerical Methods in Biomedical Engineering·Kyle M BurkJoseph A Orr
Aug 1, 1985·Respiration Physiology·R M WinslowJ Whittembury
Jan 1, 1989·Journal of Biomedical Engineering·M Sharan, A S Popel

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