Simulation of depolarization in a membrane-equations-based model of the anisotropic ventricle

IEEE Transactions on Bio-medical Engineering
G J Huiskamp

Abstract

The results of a simulation study of the propagation of depolarization in inhomogeneous anisotropic (monodomain) myocardial tissue are presented. Simulations are based on modified Beeler-Reuter membrane equations, and performed on a block of anisotropic myocardium with rotating fiber geometry, measuring 1 cm x 1 cm x 0.3 cm, at various levels of spatial discretization (0.15 mm, 0.30 mm, 0.60 mm). At a discretization level of 0.6 mm the algorithm allowed the simulation in a realistically shaped model of the ventricle, including rotational anisotropy, as well. For this simulation results are justified by comparing results for the block at various levels of discretization, for which the surface to volume ratio has been adjusted. By placing the model ventricle in a realistically shaped (human) volume conductor model, realistic body surface potentials (QRST waveforms) are simulated.

References

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Citations

Jun 30, 2009·Annals of Biomedical Engineering·Peter M van DamAdriaan van Oosterom
Dec 25, 2009·Annals of Biomedical Engineering·Muriel BoulakiaNejib Zemzemi
Mar 24, 2009·Medical & Biological Engineering & Computing·Mark PotseAlain Vinet
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Aug 8, 2015·International Journal for Numerical Methods in Biomedical Engineering·Elisa SchenoneJean-Frédéric Gerbeau
Mar 11, 2009·IEEE Transactions on Bio-medical Engineering·Mingfeng JiangStuart Crozier
Aug 18, 2004·IEEE Transactions on Bio-medical Engineering·Marie-Claude TrudelL Joshua Leon
Dec 13, 2006·IEEE Transactions on Bio-medical Engineering·Mark PotseRamesh M Gulrajani
Jan 16, 2007·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Vincent JacquemetLukas Kappenberger
Jul 10, 2003·IEEE Transactions on Bio-medical Engineering·Martin L Buist, Andrew J Pullan
May 9, 2001·IEEE Transactions on Bio-medical Engineering·R HoekemaA van Oosterom
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May 9, 2002·Physics in Medicine and Biology·Ceon RamonAkira Ishimaru

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