Simulation of melanoblast displacements reveals new features of developmental migration

Development
Pascal Laurent-GengouxLionel Larue

Abstract

To distribute and establish the melanocyte lineage throughout the skin and other developing organs, melanoblasts undergo several rounds of proliferation, accompanied by migration through complex environments and differentiation. Melanoblast migration requires interaction with extracellular matrix of the epidermal basement membrane and with surrounding keratinocytes in the developing skin. Migration has been characterized by measuring speed, trajectory and directionality of movement, but there are many unanswered questions about what motivates and defines melanoblast migration. Here, we have established a general mathematical model to simulate the movement of melanoblasts in the epidermis based on biological data, assumptions and hypotheses. Comparisons between experimental data and computer simulations reinforce some biological assumptions, and suggest new ideas for how melanoblasts and keratinocytes might influence each other during development. For example, it appears that melanoblasts instruct each other to allow a homogeneous distribution in the tissue and that keratinocytes may attract melanoblasts until one is stably attached to them. Our model reveals new features of how melanoblasts move and, in particular, suggest that...Continue Reading

References

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Citations

Sep 14, 2019·Journal of Mathematical Biology·Pascal Laurent-GengouxLionel Larue
Jul 23, 2019·The Journal of Investigative Dermatology·Melissa CrawfordLina Dagnino
Oct 3, 2020·Molecular Cancer Research : MCR·Jessica A SmartEdward J Hartsough
Mar 28, 2021·Communications Biology·Zackie AktaryLionel Larue

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Methods Mentioned

BETA
RNA-seq

Software Mentioned

Graphpad Prism
ImageJ

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