Simulation of protein-imprinted polymers. 1. Imprinted pore properties

The Journal of Physical Chemistry. B
Liora Levi, Simcha Srebnik

Abstract

Molecular imprinting is an established method for the creation of artificial recognition sites in synthetic materials through polymerization and cross-linking in the presence of template molecules. Removal of the templates leaves cavities that are complementary to the template molecules in size, shape, and functionality. Although this technique is effective when targeting small molecules, attempts to extend it to larger templates, such as proteins, have failed to show similar success. As opposed to small molecules, proteins are characterized by large size, flexible structure, and large number of functional groups available for recognition, which make it impossible to use imprinting protocols of small molecules for protein imprinting. In this research we use lattice Monte Carlo simulations of an imprinting process using radical polymerization of hydrogels as a simple model for protein-imprinted polymers (PIPs). We investigate the properties of the resulting polymer gel by studying the effects of initiator, cross-linker, and monomer concentrations and the presence of protein on gel structure and porosity. The structure and functionality of the imprinted pore is studied through diffusion of the protein inside the pore immediately ...Continue Reading

References

Mar 29, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·J H Ward, N A Peppas
Apr 2, 2002·Analytical Chemistry·Iva ChianellaAnthony P F Turner
Sep 3, 2002·Nature Biotechnology·Karsten Haupt
Apr 20, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Carmen Alvarez-Lorenzo, Angel Concheiro
Jul 23, 2004·The Journal of Chemical Physics·Keri L DiamondShelby F Thames
Sep 8, 2004·Advanced Drug Delivery Reviews·J Zachary Hilt, Mark E Byrne
Oct 29, 2005·Advanced Drug Delivery Reviews·Börje Sellergren, Chris J Allender
Nov 2, 2005·Advanced Drug Delivery Reviews·David A Spivak
Jan 6, 2006·Journal of Molecular Recognition : JMR·Cameron AlexanderMichael J Whitcombe
Aug 8, 2006·Biosensors & Bioelectronics·A BossiS A Piletsky
Aug 23, 2006·Journal of Molecular Recognition : JMR·Huiqi ZhangKlaus Mosbach
Jan 16, 2007·International Journal of Biological Macromolecules·Handan YavuzAdil Denizli
Jan 30, 2007·The Analyst·Toshifumi TakeuchiHideyuki Shinmori
Apr 21, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Ohad Kimhi, Havazelet Bianco-Peled
May 17, 2007·Analytical and Bioanalytical Chemistry·Daniel S Janiak, Peter Kofinas
Jun 5, 2007·Analytical and Bioanalytical Chemistry·Xiaoman JiangMancang Liu
Jul 13, 2007·Biomaterials·David E Hansen
Jul 17, 2007·Analytical and Bioanalytical Chemistry·Norbert M Maier, Wolfgang Lindner
Feb 28, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Carmelo Herdes, Lev Sarkisov
Jun 11, 2009·The Journal of Chemical Physics·Eduardo M A Dourado, Lev Sarkisov

❮ Previous
Next ❯

Citations

Jan 31, 2012·Industrial & Engineering Chemistry Research·David R KryscioNicholas A Peppas
Apr 5, 2014·Journal of Molecular Recognition : JMR·Michael J WhitcombeIan A Nicholls
Oct 19, 2016·Biosensors & Bioelectronics·Mohsen GolabiAnthony P F Turner
Jan 24, 2017·Journal of Molecular Recognition : JMR·Rami YankelovSimcha Srebnik
Jan 29, 2017·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·May A Abd El-AalYasser S El-Saharty
Nov 1, 2011·Journal of Molecular Recognition : JMR·Liora LeviSimcha Srebnik
Jun 22, 2018·The Journal of Physical Chemistry. B·Israel Zadok, Simcha Srebnik
Dec 2, 2010·The Journal of Physical Chemistry. B·Liora Levi, Simcha Srebnik
Oct 21, 2011·The Journal of Physical Chemistry. B·Liora Levi, Simcha Srebnik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.