Simulation of roller compaction with subsequent tableting and characterization of lactose and microcrystalline cellulose

Pharmaceutical Development and Technology
Stephanie HeinJohn Langridge

Abstract

Tablets are by far the most common solid oral dosage forms, and many drugs need to be granulated before they can be tableted. Increasingly roller compaction is being used as a dry granulation technique; however it is a very time and material intensive method. Thus some mini roller compactors and simulations of the roller compaction process have been developed as a means of studying the technique at small scale. An important factor in the selection of materials for roller compaction is their ability to be recompressed into tablets after the initial roller compaction and milling steps. In this paper the roller compaction process was simulated on the basis of some models by Gereg and Cappola (2002) and Zinchuk et al. (2004). An eccentric tableting machine was used to make compacts from alpha-lactose monohydrate, anhydrous beta-lactose, spray-dried lactose and microcrystalline cellulose at different maximum relative densities (rho rel,max 0.6-0.9). These compacts were milled immediately to granules with a rotary granulator. The properties of the granules were analyzed and compared to the properties of the original powders. These granules and powders were then tableted at different maximum relative densities (rho rel,max 0.75-0.95) ...Continue Reading

References

May 9, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·K M Picker
Aug 30, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·K M Picker
Mar 15, 2001·Pharmaceutical Development and Technology·K M Picker
Jun 27, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·J Martin Bultmann
Jan 7, 2004·International Journal of Pharmaceutics·Andrey V ZinchukBruno C Hancock
Mar 6, 2004·Pharmaceutical Development and Technology·Katharina M Picker
May 11, 2004·Drug Development and Industrial Pharmacy·Katharina M Picker
Aug 7, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Peter Kleinebudde
Sep 24, 2005·Pharmaceutical Development and Technology·Franziska FreitagPeter Kleinebudde
Apr 25, 2007·Journal of Pharmaceutical Sciences·Sy-Juen Wu, Changquan 'Calvin' Sun

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Citations

Aug 4, 2011·Drug Development and Industrial Pharmacy·Jason DawesMike Tobyn
Jan 13, 2011·Expert Opinion on Drug Delivery·Niklas Sandler, Robert Frank Lammens
Feb 17, 2010·International Journal of Pharmaceutics·J L CrispC G Blatchford
Aug 15, 2013·Pharmaceutical Development and Technology·Raman Mahadevan IyerWaseem Malick

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