Simulation of ultrasound backscattering by red cell aggregates: effect of shear rate and anisotropy

Biophysical Journal
Isabelle FontaineG Cloutier

Abstract

Tissue characterization using ultrasound (US) scattering allows extraction of relevant cellular biophysical information noninvasively. Characterization of the level of red blood cell (RBC) aggregation is one of the proposed application. In the current paper, it is hypothesized that the microstructure of the RBCs is a main determinant of the US backscattered power. A simulation model was developed to study the effect of various RBC configurations on the backscattered power. It is an iterative dynamical model that considers the effect of the adhesive and repulsive forces between RBCs, and the effect of the flow. The method is shown to be efficient to model polydispersity in size, shape, and orientation of the aggregates due to the flow, and to relate these variations to the US backscattering properties. Three levels of aggregability at shear rates varying between 0.05 and 10 s(-1) were modeled at 40% hematocrit. The simulated backscattered power increased with a decrease in the shear rate or an increase in the RBC aggregability. Angular dependence of the backscattered power was observed. It is the first attempt to model the US power backscattered by RBC aggregates polydisperse in size and shape due to the shearing of the flow.

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Citations

Aug 12, 2009·Annals of Biomedical Engineering·Marianne FenechGuy Cloutier
May 27, 2003·The Journal of the Acoustical Society of America·Isabelle Fontaine, Guy Cloutier
Aug 7, 2004·The Journal of the Acoustical Society of America·Guy CloutierF Stuart Foster
Jun 8, 2007·The Journal of the Acoustical Society of America·David Savéry, Guy Cloutier
Jul 7, 2007·The Journal of the Acoustical Society of America·François T H Yu, Guy Cloutier
Dec 13, 2012·The Journal of the Acoustical Society of America·Emilie Franceschini, Régine Guillermin
Jun 12, 2014·The Journal of the Acoustical Society of America·Emilie FranceschiniJean-François Landrier
Feb 24, 2011·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Chih-Chung Huang, Yu-Chang Chang
Dec 1, 2011·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Emilie FranceschiniGuy Cloutier
Jan 29, 2009·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Po-Hsiang TsuiChien-Cheng Chang
Sep 29, 2015·IEEE Transactions on Medical Imaging·Francois DestrempesGuy Cloutier
Jan 14, 2016·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Michael Oelze, Jonathan Mamou
Mar 4, 2005·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·David Savéry, Guy Cloutier
Oct 26, 2013·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Emilie FranceschiniGuy Cloutier
Oct 1, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Yuichi SaitoYoshio Kobayashi
Dec 22, 2009·Annals of Biomedical Engineering·J K W Chesnutt, J S Marshall
Mar 5, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ratan K Saha, Guy Cloutier
Oct 2, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Sangho KimPaul C Johnson
Dec 5, 2019·The Journal of the Acoustical Society of America·Kevin J Parker
Nov 25, 2004·The International Journal of Artificial Organs·M GrigioniV Barbaro
May 5, 2021·The Journal of the Acoustical Society of America·Lenin ChinchillaEmilie Franceschini

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