PMID: 9448939Feb 4, 1998Paper

Simulations of the effects of inositol 1,4,5-trisphosphate 3-kinase and 5-phosphatase activities on Ca2+ oscillations

Cell Calcium
G Dupont, C Erneux

Abstract

Inositol 1,4,5-trisphosphate (Ins-1,4,5-P3) is responsible for Ca2+ mobilization in response to external stimulation in many cell types. The latter phenomenon often occurs as repetitive Ca2+ spikes. In this study, the effect of the two Ins-1,4,5-P3 metabolizing enzymes (Ins-1,4,5-P3 3-kinase and 5-phosphatase) on the temporal pattern of Ca2+ oscillations has been investigated. On the basis of the well-documented Ins-1,4,5-P3 3-kinase stimulation by the Ca2+/calmodulin complex and of the experimentally-determined kinetic characteristics of these enzymes, we predict that 5-phosphatase primarily controls the levels of Ins-1,4,5-P3 and, thereby, the occurrence and frequency of Ca2+ oscillations. Consequently, the model reproduces the experimental observation performed in Chinese hamster ovary cells that 5-phosphatase overexpression has a much more pronounced effect on the pattern of Ca2+ oscillations than 3-kinase overexpression. We also investigated, in more detail, under which conditions a similar effect could be observed in other cell types expressing various Ins-1,4,5-P3 3-kinase activities.

References

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Citations

Jan 25, 2003·European Journal of Biochemistry·Stefan W Vetter, Estelle Leclerc
Mar 23, 2011·Cold Spring Harbor Perspectives in Biology·Geneviève DupontJames W Putney
Jan 5, 2011·PLoS Computational Biology·Andreja JovicShuichi Takayama
Oct 5, 2010·HFSP Journal·Geneviève Dupont, Huguette Croisier
Jan 5, 2011·Chaos·Emily HarveyMartin Wechselberger
Oct 2, 2009·Chaos·Geneviève Dupont, Laurent Combettes
Dec 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kevin Thurley, Martin Falcke
Aug 12, 2009·Journal of Biological Physics·Maurizio De PittàEshel Ben-Jacob
Jan 13, 2010·Cellular and Molecular Life Sciences : CMLS·Michael J Schell
Dec 8, 2000·Biochimica Et Biophysica Acta·G DupontL Combettes
Jul 12, 2014·Mathematical Biosciences·James SneydDavid Yule
May 8, 2016·Journal of Theoretical Biology·James SneydDavid I Yule
Feb 16, 2017·PLoS Computational Biology·Jung Min HanJames Sneyd
Feb 1, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fabrice VandeputChristophe Erneux
Feb 8, 2007·The Journal of Biological Chemistry·Samantha M Lloyd-BurtonMichael J Schell
Feb 6, 2017·Proceedings of the National Academy of Sciences of the United States of America·James SneydDavid I Yule
Mar 5, 2002·European Journal of Biochemistry·Stefan SchusterThomas Höfer
Jan 16, 2019·Bulletin of Mathematical Biology·Nathan PagesJames Sneyd
Feb 5, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G DupontL Combettes
Apr 23, 2021·Biophysical Journal·Victor Nicolai FriedhoffFabio M Simões de Souza
Dec 5, 1998·Biochimica Et Biophysica Acta·P J Cullen
Dec 5, 1998·Biochimica Et Biophysica Acta·C ErneuxX Pesesse

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