Apr 25, 2020

Flexible machine learning prediction of antigen presentation for rare and common HLA-I alleles

BioRxiv : the Preprint Server for Biology
B. BraviA. M. Walczak

Abstract

The recent increase of immunopeptidomic data, obtained by mass spectrometry (MS) or binding assays, opens unprecedented possibilities for investigating endogenous antigen presentation by the highly polymorphic human leukocyte antigen class I (HLA-I) protein. We introduce a flexible and easily interpretable peptide presentation prediction method. We validate its performance as a predictor of cancer neoantigens and viral epitopes and use it to reconstruct peptide motifs presented on specific HLA-I molecules.

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