PMID: 11897855Mar 19, 2002Paper

Simultaneous activation of gamma and theta network oscillations in rat hippocampal slice cultures

The Journal of Physiology
Yacov FischerB H Gähwiler

Abstract

Hippocampal activity in vivo is characterized by concurrent oscillations at theta (4-15 Hz) and gamma (20-80 Hz) frequencies. Here we show that cholinergic receptor activation (methacholine 10-20 nm) in hippocampal slice cultures induces an oscillatory mode of activity, in which the intrinsic network oscillator (located in the CA3 area) expresses simultaneous theta and gamma network oscillations. Pyramidal cells display synaptic theta oscillations, characterized by cycles consisting of population EPSP-IPSP sequences that are dominated by population IPSPs. These rhythmic IPSPs most probably result from theta-modulated spiking activity of several interneurons. At the same time, the majority of interneurons consistently display synaptic gamma oscillations. These oscillatory cycles consist of fast depolarizing rhythmic events that are likely to reflect excitatory input from CA3 pyramidal cells. Interneurons comprising this functional group were identified morphologically. They include four known types of interneurons (basket, O-LM, bistratified and str. lucidum-specific cells) and one new type of CA3 interneuron (multi-subfield cell). The oscillatory activity of these interneurons is only weakly correlated between neighbouring cell...Continue Reading

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Citations

Oct 12, 2012·Journal of Computational Neuroscience·Julia BerzhanskayaGiorgio A Ascoli
Feb 22, 2003·Molecular and Cellular Neurosciences·Sari E LauriTomi Taira
Jun 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jeanne SterUrs Gerber
Nov 9, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Juan C Piña-CrespoStuart A Lipton
Nov 13, 2004·The Journal of Physiology·Jo Watts, Alex M Thomson
Dec 18, 2003·The Journal of Physiology·Yacov Fischer
Nov 11, 2008·Computers in Biology and Medicine·June Sic KimChun Kee Chung
Dec 13, 2006·The European Journal of Neuroscience·James L Sinfield, Dawn R Collins
Sep 21, 2007·The European Journal of Neuroscience·Harald HentschkeMatthew I Banks
Sep 3, 2013·Statistics in Medicine·Reza RamezanShojaeddin Chenouri
May 4, 2004·Trends in Cognitive Sciences·Scott MakeigArnaud Delorme
Mar 27, 2015·Journal of Neuroscience Research·Justus SchneiderOliver Kann
Aug 18, 2009·Neural Networks : the Official Journal of the International Neural Network Society·Norbert Hájos, Ole Paulsen
Mar 26, 2013·Neuron·John E Lisman, Ole Jensen
Aug 11, 2007·Neuropharmacology·Miranda A KarsonBradley E Alger
Jul 6, 2016·Frontiers in Molecular Neuroscience·Oliver KannJustus Schneider
Jul 3, 2016·Brain Structure & Function·Zhenglin Gu, Jerrel L Yakel

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