Simultaneous Amelioratation of Colitis and Liver Injury in Mice by Bifidobacterium longum LC67 and Lactobacillus plantarum LC27

Scientific Reports
Se-Eun JangDong-Hyun Kim

Abstract

Disturbances in the gut microbiota composition are associated with chronic inflammatory diseases of the intestine and the liver. In a preliminary study, Lactobacillus plantarum LC27 and Bifidobacterium longum LC67 could inhibit Escherichia coli growth and lipopolysaccharide-induced NF-κB activation linked to gut inflammation. Here, we investigated their effects on 2,4,6-trinitrobenzesulfonic acid (TNBS)-induced colitis and liver damage in mice. First, oral administration of LC27 or LC67 (1 × 109 CFU/mouse) inhibited TNBS-induced colon shortening [F(5,30) = 100.66, P < 0.05] and myeloperoxidase activity [F(5,30) = 56.48, P < 0.05]. These probiotics restored TNBS-induced disturbance of gut microbiota, leading to the suppression of Proteobacteria to Bacteroidetes ratio and fecal and blood lipopolysaccharide levels. Second, LC27 and LC67 inhibited TNBS-induced NF-κB activation, reversed TNBS-suppressed tight junction protein expression, and restored Th17/Treg balance. Also, treatment with LC27 or LC67 significantly decreased TNBS-induced alanine transaminase [ALT, F(5,30) = 3.50, P < 0.05] and aspartate transaminase [AST, F(5,30) = 12.81, P < 0.05] levels in the blood, as well as t-butylhydroperoxide-induced ALT and AST levels. Fin...Continue Reading

References

Jan 19, 1999·Gastroenterology Clinics of North America·J P Katz, G R Lichtenstein
Jul 11, 2001·Immunologic Research·J Hawiger
Aug 3, 2004·Nature Medicine·Anne O'Garra, Paulo Vieira
Sep 16, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Hae-Ung LeeDong-Hyun Kim
Feb 5, 2008·Nutrition Reviews·Bruce Bistrian
Oct 5, 2010·Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry·Elaine O Petrof
Oct 26, 2011·Journal of Innate Immunity·Allan McI Mowat, Calum C Bain
Mar 5, 2013·Cold Spring Harbor Perspectives in Medicine·Judith BehnsenManuela Raffatellu
Jul 24, 2013·Journal of Gastroenterology and Hepatology·Eric S OrmanRamon Bataller
Jun 20, 2014·Immunological Reviews·Katie L AlexanderCharles O Elson
Aug 19, 2014·Trends in Pharmacological Sciences·Jianfei YangTetsuya Yamagata
Jan 7, 2015·World Journal of Gastroenterology : WJG·Li ZuoDing-Hua Yang
Jun 1, 2013·Journal of Clinical and Experimental Hepatology·Manan Bawa, Vivek A Saraswat
Apr 14, 2015·Systematic and Applied Microbiology·Senthil Alias SankarPierre-Edouard Fournier
May 1, 2015·Digestive Diseases·Charles O Elson, Katie L Alexander
Aug 13, 2015·Current Drug Metabolism·Roland KirschnerShir-Ly Huang
Sep 5, 2015·Gut·Julian R MarchesiAilsa Hart
Sep 24, 2015·Journal of Food Science and Technology·Bathal Vijaya KumarObulam Vijaya Sarathi Reddy
Nov 26, 2015·Journal of Nutritional Science and Vitaminology·Hye-Ji Kang, Sin-Hyeog Im
Mar 2, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Su-Min LimDong-Hyun Kim
Apr 5, 2016·The Journal of Medical Investigation : JMI·Keiko Kataoka
Apr 7, 2016·Best Practice & Research. Clinical Gastroenterology·Tanvir R Haque, A Sidney Barritt
Apr 9, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jacob R EmgeMélanie G Gareau
Oct 27, 2016·Journal of Leukocyte Biology·John J Seeley, Sankar Ghosh

❮ Previous
Next ❯

Citations

Aug 3, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Naama Geva-ZatorskySven Pettersson
Oct 19, 2019·Microbiology and Immunology·Se-Eun Jang, Sung-Won Min
Aug 5, 2020·Applied Microbiology and Biotechnology·Se Hee LeeChe Ok Jeon
May 10, 2020·Alimentary Pharmacology & Therapeutics·Timur LiwinskiChristoph Schramm
Jan 18, 2020·Scientific Reports·Shiro MawatariTakehiko Fujino
Aug 3, 2021·Journal of Immunology Research·Shunyu YaoXiaolu Liu
Jun 29, 2021·Current Pharmaceutical Design·Tanya RalliKanchan Kohli

❮ Previous
Next ❯

Methods Mentioned

BETA
GAM
ELISA
FACS
flow cytometry
MDA
PCR
electrophoresis

Software Mentioned

Excel

Related Concepts

Related Feeds