PMID: 11909651Mar 23, 2002Paper

Simultaneous analysis of gamma-hydroxybutyric acid, gamma-butyrolactone, and 1,4-butanediol by micellar electrokinetic chromatography

Forensic Science International : Synergy
Johan Dahlén, Thyrsa Vriesman

Abstract

A micellar electrokinetic chromatography (MEKC) method was optimised for simultaneous analysis of gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL), and 1,4-butanediol (BD). Best conditions for separation and baseline stability were achieved using a carrier electrolyte comprising 30.0mM sodium barbital and 150.0mM sodium dodecyl sulphate (SDS) at pH 10.2. Calibration functions were linear, giving correlation coefficients (r(2)) >0.998 for the three target compounds. Limits of detection (LOD) defined as three times the noise, were 5.1mg/l, 0.34 and 0.25g/l for GHB, GBL and BD, respectively. The repeatability of migration times and peak areas, expressed as the R.S.D. (n = 9) was better than 0.41 and 3.05%, respectively. Some casework samples were analysed using the optimised conditions.

References

Sep 28, 1987·Life Sciences·P VayerM Maitre
Sep 1, 1994·International Clinical Psychopharmacology·G GerraA Mutti
Jun 1, 1993·Journal of Pharmaceutical and Biomedical Analysis·S D FerraraP Palatini
Feb 9, 1996·Forensic Science International : Synergy·F TagliaroF P Smith
Apr 1, 1997·Science & Justice : Journal of the Forensic Science Society·P EsseivaM D Cole
Feb 10, 1998·Electrophoresis·F von Heeren, W Thormann
Mar 13, 1999·Journal of Biochemical and Biophysical Methods·I Bjørnsdottir, S H Hansen
Sep 17, 1999·Journal of Analytical Toxicology·R R McCuskerB A Goldberger
Mar 22, 2000·Forensic Science International : Synergy·A A Elian

❮ Previous
Next ❯

Citations

Mar 26, 2004·Forensic Science International : Synergy·Simon ElliottAmanda Symonds
Apr 7, 2004·Forensic Science International : Synergy·Sandra C BishopBruce R McCord
Dec 31, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Federica BortolottiFranco Tagliaro
Apr 13, 2011·Forensic Science International : Synergy·Johan DahlénMalin Jonsson
Jan 20, 2006·Electrophoresis·Franco Tagliaro, Federica Bortolotti
Aug 10, 2004·Toxicological Reviews·Cynthia L Morris-Kukoski
Aug 30, 2003·Analytical Chemistry·T A BrettellR Saferstein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Federica BortolottiF Tagliaro
Forensic Science International : Synergy
Eckhard Kaufmann, Andreas Alt
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Benoît BlanchetAlain Astier
© 2022 Meta ULC. All rights reserved