Simultaneous Analysis of Iridoid Glycosides and Anthraquinones in Morinda officinalis Using UPLC-QqQ-MS/MS and UPLC-Q/TOF-MSE

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Xiangsheng ZhaoMeihua Yang

Abstract

Morinda officinalis is an important herbal medicine and functional food, and its main constituents include anthraquinone and iridoid glycosides. Quantification of the main compounds is a necessary step to understand the quality and therapeutic properties of M. officinalis, but this has not yet been performed based on liquid chromatography/tandem mass spectrometry (LC-MS/MS). Analytes were extracted from M. officinalis by reflux method. Ultrahigh-performance liquid chromatography coupled with a triple quadrupole mass spectrometry (UPLC-QqQ-MS) using multiple reaction monitoring (MRM) mode was applied for quantification. Fragmentation pathways of deacetyl asperulosidic acid and rubiadin were investigated based on UPLC with quadrupole time-of-flight tandem mass spectrometry (Q/TOF-MS) in the MSE centroid mode. The method showed a good linearity over a wide concentration range (R² ≥ 0.9930). The limits of quantification of six compounds ranged from 2.6 to 27.57 ng/mL. The intra- and inter-day precisions of the investigated components exhibited an RSD within 4.5% with mean recovery rates of 95.32⁻99.86%. Contents of selected compounds in M. officinalis varied significantly depending on region. The fragmentation pathway of deacety...Continue Reading

References

Oct 6, 2005·Biological & Pharmaceutical Bulletin·Jongwon ChoiHee-Juhn Park
Jan 20, 2009·International Journal of Biological Macromolecules·Hua-Lin ZhangDe-po Yang
Jan 27, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yan-Bin WuJin-Zhong Wu
Sep 29, 2011·Chemico-biological Interactions·Leilei BaoQiaoyan Zhang
Mar 10, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Zhifeng LiShilin Yang
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Aug 16, 2016·Journal of Pharmaceutical and Biomedical Analysis·Qingfeng LiuMingkang Zhong

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Citations

Nov 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yanyan ZhouBaolin Bian
Jan 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiangsheng ZhaoJianhe Wei
Dec 17, 2019·Phytotherapy Research : PTR·Bharat Singh, Ram A Sharma
Jun 11, 2020·Food Research International·Irina LazarovaMohamad Fawzi Mahomoodally
Dec 9, 2020·Food Research International·Hongkang ZhuHe Qian

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