Simultaneous analysis of six major compounds in Osterici Radix and Notopterygii Rhizoma et Radix by HPLC and discrimination of their origins from chemical fingerprint analysis

Archives of Pharmacal Research
Sungun KimWan Kyunn Whang

Abstract

Osterici Radix, the dried roots of Ostericum koreanum Maximowicz, has long been used to treat cold, headache and arthralgia in Chinese medicine. Notopterygii Rhizoma et Radix, the dried rhizomes and roots of Notopterygium incisum Ting et H.T. Chang or Notopterygium forbesii Boiss (family: Umbelliferae), are well-known traditional Chinese medicines. These all herbal medicines were named kangwhoal in China, Japan and Korea. However no discrimination methods for the origin and no simultaneous analysis methods for bioactive components are currently available. We developed simultaneous analysis of six biomarkers including nodakenin (1), oxypeucedanin (2), bisabolangelone (3), notopterol (4), imperatorin (5), and isoimperatorin (6) using HPLC method. HPLC chromatographic separation was conducted with C18 column and mobile phase of acetonitrile (A) - water (B) (gradient, (A) 35%-65% (30 min)). The analytical condition was validated with specificity, selectivity, linearity (correlation coefficients of all bio marker were more than 0.999.), recovery (94.9-106.8%), precision and accuracy (intra and inter RSD < 2.99%). In addition, principal component analysis and cluster analysis was performed on analytical data of 38 commercial kangwhoa...Continue Reading

References

May 1, 1993·Chemical & Pharmaceutical Bulletin·E OkuyamaM Yamazaki
Aug 12, 1999·Biological & Pharmaceutical Bulletin·A HasegawaM Kitada
Jul 3, 2007·Chemical & Pharmaceutical Bulletin·Yeo Jin ParkYong Sup Lee
Jul 29, 2008·Journal of Chromatography. a·Xin-miao LiangYuan-sheng Xiao
Jul 19, 2011·Planta medica·Mei YouJin-Feng Hu

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Citations

Nov 10, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Kyungjin LeeHo-Young Choi
Sep 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna HawryłŁukasz Komsta
Aug 29, 2021·Plants·Javad Mottaghipisheh

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