Abstract
Radiofrequency (RF) and high-intensity focused electromagnetic (HIFEM) technologies are used for noninvasive body shaping as standalone modalities. To examine the effects of novel synchronized RF and HIFEM on subcutaneous adipose tissue in a porcine animal model. Seven large white pigs aged 6 months received 3 abdominal treatments of simultaneous application of synchronized RF and HIFEM (30 minutes, once per week). Punch biopsies of treated and control subcutaneous tissue were collected at the baseline, 4 days, 2 weeks, 1 month, and 2 months. Specimens were examined by light and scanning electron microscopy. Adipocyte volume was analyzed. Fat tissue temperature was measured in situ (fiber optic probes) and superficially (thermal imager). Fat layer was heated to temperatures of 42 to 45°C. Signs of fat apoptosis (shape alternations and pyknotic nuclei) appeared at day 4 and peaked between 2 weeks and 1 month. Adipocyte volume decreased significantly (p < .001) by 31.1% at 2 weeks, 1 month (-23.6%), and 2 months (-22.0%). Control samples showed healthy adipocytes. Scanning electron microscopy micrographs corroborated histology findings, showing flattened, volume-depleted and disrupted adipocytes. Synchronized RF with HIFEM proced...Continue Reading
References
Jun 1, 1990·IEEE Transactions on Bio-medical Engineering·B J Roth, P J Basser
Jun 1, 1989·British Journal of Sports Medicine·G C Goats
Nov 28, 2007·Annual Review of Pathology·Kenneth L Rock, Hajime Kono
Oct 28, 2008·Lasers in Surgery and Medicine·Dieter MansteinR Rox Anderson
Nov 28, 2008·Aesthetic Plastic Surgery·Mario A Trelles, Serge R Mordon
Mar 27, 2009·Lasers in Medical Science·Mario A TrellesMarwan Al-Zarouni
Nov 23, 2010·Progress in Lipid Research·Achim LassRudolf Zechner
Nov 23, 2010·Nature Reviews. Immunology·Grace Y Chen, Gabriel Nuñez
May 24, 2013·Adipocyte·Junghyo JoVipul Periwal
Jan 28, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Yusuke YokoyamaKayoko Matsunaga
Feb 19, 2014·Lasers in Surgery and Medicine·Sylvie BoisnicGary P Lask
Apr 2, 2014·Lasers in Medical Science·Maurice A AdattoGrietje Morren
Apr 3, 2015·Physiological Reviews·Michael J Joyner, Darren P Casey
Jun 13, 2015·F1000Research·Jiri PumprlaEliska Sovova
Jan 7, 2016·Ophthalmic Plastic and Reconstructive Surgery·Qianwen WangTailing Wang
Mar 11, 2016·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Diane Irvine DuncanRobbin Temaat
Jan 20, 2017·Lasers in Surgery and Medicine·John W DecoratoRafael Sierra
Jun 2, 2017·Lasers in Medical Science·Patrícia Froes MeyerCiro Dantas Soares
Sep 19, 2018·Journal of Cosmetic Dermatology·Ana Luísa ValePaulo Carvalho
Dec 15, 2018·Lasers in Surgery and Medicine·Robert A Weiss, Jan Bernardy
Oct 31, 2019·Aesthetic Surgery Journal·Diane Duncan, Ivan Dinev
Dec 4, 2019·Journal of Cosmetic Dermatology·Brian M KinneyPenka Yonkova
Jan 17, 2020·Journal of Cosmetic Dermatology·Yael Halaas, Jan Bernardy