Simultaneous assessment of both lung morphometry and gas exchange function within a single breath-hold by hyperpolarized129 Xe MRI

NMR in Biomedicine
Jianping ZhongXin Zhou

Abstract

During the measurement of hyperpolarized129Xe magnetic resonance imaging (MRI), the diffusion-weighted imaging (DWI) technique provides valuable information for the assessment of lung morphometry at the alveolar level, whereas the chemical shift saturation recovery (CSSR) technique can evaluate the gas exchange function of the lungs. To date, the two techniques have only been performed during separate breaths. However, the request for multiple breaths increases the cost and scanning time, limiting clinical application. Moreover, acquisition during separate breath-holds will increase the measurement error, because of the inconsistent physiological status of the lungs. Here, we present a new method, referred to as diffusion-weighted chemical shift saturation recovery (DWCSSR), in order to perform both DWI and CSSR within a single breath-hold. Compared with sequential single-breath schemes (namely the 'CSSR + DWI' scheme and the 'DWI + CSSR' scheme), the DWCSSR scheme is able to significantly shorten the breath-hold time, as well as to obtain high signal-to-noise ratio (SNR) signals in both DWI and CSSR data. This scheme enables comprehensive information on lung morphometry and function to be obtained within a single breath-hold. ...Continue Reading

References

Dec 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H Gudbjartsson, S Patz
Nov 1, 1996·Journal of Magnetic Resonance. Series B·L ZhaoM S Albert
Jun 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J P MuglerM E Wagshul
Sep 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K RuppertJ P Mugler
Mar 10, 2001·Journal of Magnetic Resonance Imaging : JMRI·T A AltesJ R Brookeman
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Dmitriy A YablonskiyMark S Conradi
May 14, 2003·Journal of Physics. Condensed Matter : an Institute of Physics Journal·J P ButlerS Patz
Dec 4, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sven MånssonKlaes Golman
Feb 21, 2006·Physical Review Letters·I C RusetF W Hersman
Jun 13, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nishard AbdeenGiles Santyr
Sep 8, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Robert TrampelGlyn Johnson
Oct 24, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jason C WoodsJames C Hogg
Nov 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bastiaan DriehuysG Allan Johnson
Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·John P MuglerKai Ruppert
Feb 22, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Wei WangJason C Woods
Mar 18, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S Sivaram KaushikBastiaan Driehuys
Jun 30, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A L Sukstanskii, D A Yablonskiy
Feb 2, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiaojun XuJim M Wild
Mar 2, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mathieu BoudreauGiles E Santyr
May 9, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yulin V Chang
Sep 27, 2012·Journal of Magnetic Resonance Imaging : JMRI·Iga MuradyanSamuel Patz
Jan 29, 2013·Journal of Magnetic Resonance Imaging : JMRI·John P Mugler, Talissa A Altes
Jan 30, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alexei OuriadovGiles E Santyr
May 18, 2013·Journal of Magnetic Resonance Imaging : JMRI·Kun QingJohn P Mugler
Aug 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Panayiotis NikolaouBoyd M Goodson
Oct 25, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yulin V ChangJason C Woods
Jan 8, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·General LeungJim M Wild
May 7, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yulin V ChangDmitriy A Yablonskiy
Aug 12, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Neil J StewartJim M Wild
Dec 9, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A OuriadovG E Santyr
May 15, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Madhwesha Rao, Jim M Wild
May 20, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S Sivaram KaushikBastiaan Driehuys
Jul 15, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alexei OuriadovGiles E Santyr
Sep 25, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Haidong LiXin Zhou
Nov 7, 2015·Journal of Applied Physiology·James D QuirkDmitriy A Yablonskiy

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Citations

Apr 24, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kai RuppertRahim R Rizi
Dec 24, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ming ZhangXin Zhou
Jun 20, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kai RuppertRahim R Rizi
Jan 15, 2019·Journal of Magnetic Resonance Imaging : JMRI·Andrew WestcottAlexei Ouriadov

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