PMID: 9430343Jun 1, 1997Paper

Simultaneous assessment of flow and BOLD signals in resting-state functional connectivity maps

NMR in Biomedicine
B B BiswalJ S Hyde

Abstract

We have recently demonstrated using functional magnetic resonance imaging the presence of synchronous low-frequency fluctuations of signal intensities from the resting human brain that have a high degree of temporal correlation (p < 0.0001) both within and across the sensorimotor cortex. A statistically significant overlap between the resting-state functional connectivity map and the task-activation map due to bilateral finger tapping was obtained. Similar results have been obtained in the auditory and visual cortex. Because the pulse sequence used for collecting data was sensitive to blood flow and blood oxygenation, these low-frequency fluctuations of signal intensity may have arisen from variations of both. The objective of this study was simultaneously to determine the contribution of the blood oxygenation level signal and the flow signal to physiological fluctuations in the resting brain using the flow-sensitive alternating inversion recovery pulse sequence. In all subjects, the functional connectivity maps obtained from BOLD had a greater coincidence with task-activation maps than the corresponding functional connectivity maps obtained from blood-flow signals at the same level of statistical significance. Results of this ...Continue Reading

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Citations

Sep 21, 2010·Brain Structure & Function·Shella D KeilholzGarth Thompson
Jun 4, 2010·Magma·Veronika SchöpfEwald Moser
May 18, 2010·Magma·Philipp G SämannMichael Czisch
Mar 20, 2012·Magma·David C Alsop
May 11, 2013·Brain Topography·Jacco A de ZwartJeff H Duyn
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Aug 21, 2007·Nature Reviews. Neuroscience·Michael D Fox, Marcus E Raichle
Oct 3, 2012·Brain Connectivity·Xin DiUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Feb 9, 2010·Cerebral Cortex·Maki S KoyamaMichael P Milham
Aug 16, 2011·Cerebral Cortex·R Matthew HutchisonStefan Everling
Nov 8, 2008·Schizophrenia Bulletin·Robert C WelshStephan F Taylor
Aug 10, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Silke DodelJean-Baptiste Poline
Apr 27, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Brett FroeligerPaul Sobin
Nov 26, 2009·BMC Neuroscience·Simon RobinsonEwald Moser
Apr 24, 2008·PloS One·Martijn van den HeuvelHilleke Hulshoff Pol
Dec 17, 2009·PloS One·Toru NakamuraBharat B Biswal
Jul 3, 2013·PloS One·Zhentao ZuoDanny J J Wang
Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mohammadreza NasiriavanakiLihong V Wang
Aug 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·D MantiniM Corbetta
Aug 6, 2013·Social Cognitive and Affective Neuroscience·Matthew J SchreinerCarrie E Bearden
Oct 15, 2014·Proceedings of the National Academy of Sciences of the United States of America·Congwu DuYingtian Pan
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Oct 14, 2005·Journal of Neurophysiology·Jonas LarssonDavid J Heeger
May 12, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Denis SchluppeckDavid J Heeger

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