Simultaneous Bayesian inference of phylogeny and molecular coevolution

Proceedings of the National Academy of Sciences of the United States of America
Xavier MeyerNicolas Salamin

Abstract

Patterns of molecular coevolution can reveal structural and functional constraints within or among organic molecules. These patterns are better understood when considering the underlying evolutionary process, which enables us to disentangle the signal of the dependent evolution of sites (coevolution) from the effects of shared ancestry of genes. Conversely, disregarding the dependent evolution of sites when studying the history of genes negatively impacts the accuracy of the inferred phylogenetic trees. Although molecular coevolution and phylogenetic history are interdependent, analyses of the two processes are conducted separately, a choice dictated by computational convenience, but at the expense of accuracy. We present a Bayesian method and associated software to infer how many and which sites of an alignment evolve according to an independent or a pairwise dependent evolutionary process, and to simultaneously estimate the phylogenetic relationships among sequences. We validate our method on synthetic datasets and challenge our predictions of coevolution on the 16S rRNA molecule by comparing them with its known molecular structure. Finally, we assess the accuracy of phylogenetic trees inferred under the assumption of indepen...Continue Reading

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Citations

Apr 11, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Arshan NasirGustavo Caetano-Anollés
May 28, 2021·Molecular Biology and Evolution·Andrew F MageeWilliam S DeWitt

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