Simultaneous carboplatin and radiotherapy for all stages of head and neck squamous cell carcinoma

Clinical Oncology : a Journal of the Royal College of Radiologists
Y HosokawaY Inuyama

Abstract

The study investigated the toxicity and efficiency of the concomitant administration of radiotherapy and carboplatin to patients with head and neck carcinomas. Sixty-three patients with head and neck squamous cell carcinomas, other than nasopharyngeal cancer and Stage I (UICC) laryngeal cancers, were treated by external radiotherapy and four courses of carboplatin at a dose of 100 mg/m2 per week. In two patients, only three courses were possible due to renal toxicity. In the other 61 patients, toxicities were self-limiting and no patient required interruption of carboplatin administration. No patient required discontinuation of radiotherapy because of acute toxicity. Of 61 evaluable patients, a complete response (CR) was obtained in 11.5% and a partial response (PR) in 60.7% at 40 Gy. In 41 patients treated to 65 Gy (including two patients with maxillary sinus carcinoma, who were treated by debulking surgery), CR was obtained in 76.9% and CR+PR was 100% at the end of treatment. The actuarial survival rate of the 63 patients at 2 years was 69.2%, with a median follow-up period of 24.4 months. One of 12 patients who received salvage surgery after radical radiotherapy has died due to poor wound healing after the surgery. The sched...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·G E LaramoreJ G Schwade
Jun 13, 1991·The New England Journal of Medicine·UNKNOWN Department of Veterans Affairs Laryngeal Cancer Study GroupWilliam G Henderson
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Jan 1, 1993·Clinical Oncology : a Journal of the Royal College of Radiologists·S P AcklandJ W Denham

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Citations

Jul 23, 2003·International Journal of Radiation Oncology, Biology, Physics·Alfonso Duenas-GonzalezJaime de la Garza
Jun 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Savita LasradoNeil Aaron Luis

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