Simultaneous cerebrospinal fluid and hematologic metastases in a high-grade ependymoma

Surgical Neurology International
Daniel Diaz-AguilarShayan Rahman

Abstract

Ependymomas are relatively uncommon tumors that constitute about 7% of all primary intracranial neoplasms. Among these, high-grade ependymomas are locally aggressive and recur most commonly at the primary site following resection. Ependymomas are also known to be the one glial neoplasm that tends to frequently metastasize inside and outside the central nervous system (CNS) that complicates workup and management. Metastasis due to surgical manipulation is common and neurosurgeons should be well-versed in the most effective methods to remove these tumors in order to avoid such metastases. Here, we report a case of a 28-year-old female who initially presented with a parenchymal World Health Organization (WHO) grade III anaplastic ependymoma of the occipital lobe without metastasis. After multiple resections, the patient showed no evidence of disease recurrence for 2 years. During follow-up, new metastasis to the frontal lobe as well as to the lung were discovered 2 years after the initial surgery, without recurrence at the tumor's primary site. While uncommon, this case demonstrates the possibility for ependymomas to metastasize via cerebrospinal fluid to other locations within the CNS and hematologically to extraneural locations ...Continue Reading

References

Nov 1, 1977·Journal of Neurosurgery·C MavroudisC B Wilson
May 1, 1990·Neurologia Medico-chirurgica·J ItohY Hashizume
Dec 1, 1973·Journal of Clinical Pathology·D G WightJ A Finbow
Jun 1, 1981·Gynecologic Oncology·E Björkholm, C Silfverswärd
Sep 1, 1981·Annals of Neurology·P K Duffner, M E Cohen
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Feb 13, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Catherine Godfraind
May 22, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Kyu-Won ShimJoong-Uhn Choi
Apr 29, 2010·Current Neurology and Neuroscience Reports·Mark R GilbertRiccardo Soffietti
Sep 11, 2010·Pediatric Blood & Cancer·Mwe Mwe ChaoBrian R Rood
Oct 1, 2011·Chinese Journal of Cancer·Yuan YaoMichael D Taylor
Sep 15, 2012·Pediatric Blood & Cancer·Cheryl FischerYasmin Khakoo
Apr 23, 2014·The Neuroradiology Journal·Ahmed AlzahraniReem Zakzouk
Aug 15, 2014·Neuro-oncology·Elizabeth Vera-BolanosUNKNOWN CERN Foundation
Mar 30, 2016·Neuro-oncology·Jing WuMark R Gilbert
Nov 28, 2016·Neuroimaging Clinics of North America·Lara A Brandão, Tina Young Poussaint
Jun 24, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas E Merchant
Aug 3, 2017·Endocrine Pathology·Ozgur Mete, M Beatriz Lopes

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Methods Mentioned

BETA
biopsies
X-ray
biopsy
surgical resection

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