Simultaneous changes in expression levels of BAALC and miR-326: a novel prognostic biomarker for childhood ALL

Japanese Journal of Clinical Oncology
Elaheh S GhodousiSoheila Rahgozar

Abstract

Multidrug resistance and consequent relapse are two major obstacles for treating children with acute lymphoblastic leukemia, the most frequent childhood malignancy. MicroRNAs have potential regulatory roles in response to chemotherapy. The goal of this study was to determine the microRNA that may have effects on the expression level of brain and acute lymphoblastic leukemia (BAALC) and to investigate the in vitro and ex vivo association between their expression levels. In silico tools were utilized to determine a putative miRNA targeting BALLC. Quantitative real-time polymerase chain reaction was used to investigate expression levels of BAALC and its predicted microRNA, miR-326, in bone marrow samples of 30 children with acute lymphoblastic leukemia and 13 controls, in addition to the resistant and parental CCRF-CEM cell lines. To assess the status of response to therapy, minimal residual disease was measured using single-strand conformation polymorphism. MiR-326 was selected due to the strong possibility of its interaction with BAALC according to the obtained in silico results. Statistical analysis showed a significant downregulation of miR-326 and overexpression of BALLC in drug-resistant acute lymphoblastic leukemia cell lin...Continue Reading

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Citations

Jan 21, 2021·International Journal of Molecular Sciences·Anna MroczekMonika Lejman
Jun 3, 2021·International Journal of Molecular Sciences·Katarzyna GębarowskaMonika Lejman

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