Simultaneous co-detection of wild-type and vaccine strain measles virus using the BD MAX system

Pathology
Kiran ThapaJen Kok

Abstract

Despite the reported elimination of measles virus in Australia, importation of cases from endemic countries continues to lead to secondary local transmission and outbreaks. Rapid laboratory confirmation of measles is paramount for individual patient management and outbreak responses. Further, it is important to rapidly distinguish infection from wild-type virus or vaccine strains to guide public health responses. We developed a high throughput, TaqMan-based multiplex reverse-transcription-polymerase chain reaction (PCR) assay using the BD MAX platform (Becton Dickinson) that simultaneously detects measles virus and differentiates between wild-type and vaccine strains without the need for sequencing.

Citations

Nov 14, 2019·The New England Journal of Medicine·William D Rawlinson, Pamela Palasanthiran
Mar 20, 2020·Australian and New Zealand Journal of Public Health·Heidi LordKate Alexander
Oct 16, 2019·Journal of Paediatrics and Child Health·Yean H EweBrendan McMullan

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