Simultaneous delivery time and aperture shape optimization for the volumetric-modulated arc therapy (VMAT) treatment planning problem

Physics in Medicine and Biology
Mehdi MahnamLouis-Martin Rousseau

Abstract

In this paper, we propose a novel heuristic algorithm for the volumetric-modulated arc therapy treatment planning problem, optimizing the trade-off between delivery time and treatment quality. We present a new mixed integer programming model in which the multi-leaf collimator leaf positions, gantry speed, and dose rate are determined simultaneously. Our heuristic is based on column generation; the aperture configuration is modeled in the columns and the dose distribution and time restriction in the rows. To reduce the number of voxels and increase the efficiency of the master model, we aggregate similar voxels using a clustering technique. The efficiency of the algorithm and the treatment quality are evaluated on a benchmark clinical prostate cancer case. The computational results show that a high-quality treatment is achievable using a four-thread CPU. Finally, we analyze the effects of the various parameters and two leaf-motion strategies.

References

May 30, 2003·Medical Physics·Joseph O DeasyVanessa H Clark
Apr 22, 2005·Physics in Medicine and Biology·Alexander ScherrerFernando Alonso
Feb 26, 2008·Medical Physics·Shuang LuanCedric X Yu
Oct 21, 2009·Physics in Medicine and Biology·Daliang CaoDavid M Shepard
Dec 17, 2010·Medical Physics·Chunhua MenSteve B Jiang
Feb 8, 2011·Physics in Medicine and Biology·Cedric X Yu, Grace Tang
Feb 11, 2012·Medical Physics·David CraftThomas Bortfeld
Jun 23, 2012·Physics in Medicine and Biology·Fei PengSteve B Jiang
Sep 7, 2012·Physics in Medicine and Biology·Jeremiah WalaDavid Craft
Mar 5, 2015·Medical Physics·Jan UnkelbachEhsan Salari
Mar 20, 2015·Physics in Medicine and Biology·Fei PengMarina A Epelman
Jan 5, 2017·Physics in Medicine and Biology·Marleen Balvert, David Craft

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Citations

Feb 23, 2019·Physics in Medicine and Biology·Mehdi MahnamLouis-Martin Rousseau
Sep 5, 2019·Physics in Medicine and Biology·Pınar DursunEthem Nezih Oral
Mar 13, 2021·Physics in Medicine and Biology·Pınar DursunJoseph O Deasy

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