Simultaneous detection of circulating immunological parameters and tumor biomarkers in early stage breast cancer patients during adjuvant chemotherapy

Cellular Oncology (Dordrecht)
Bianca RovatiPaolo Pedrazzoli

Abstract

Chemotherapy-induced immune suppression has mainly been studied in patients with advanced cancer, but the influence of chemotherapy on the immune system in early stage cancer patients has so far not been studied systematically. The aim of the present study was to monitor the immune system during anthracycline- and taxane-based adjuvant chemotherapy in early stage breast cancer patients, to assess the impact of circulating tumor cells on selected immune parameters and to reveal putative angiogenic effects of circulating endothelial cells. Peripheral blood samples from 20 early stage breast cancer patients were analyzed using a flow cytometric multi-color of antibodies to enumerate lymphocyte and dendritic cell subsets, as well as endothelial and tumor cells. An enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of various serological factors. During chemotherapy, all immunological parameters and angiogenesis surrogate biomarkers showed significant decreases. The numbers of circulating tumor cells showed significant inverse correlations with the numbers of T helper cells, a lymphocyte subset directly related to effective anti-tumor responses. Reduced T helper cell numbers may contribute to systemic immunosup...Continue Reading

References

Nov 11, 1993·International Journal of Cancer. Journal International Du Cancer·H F SewellR W Blamey
Jul 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R R MehtaT K Das Gupta
Jul 23, 1999·Frontiers in Bioscience : a Journal and Virtual Library·R V Gardner
Aug 15, 2000·Cancer Immunology, Immunotherapy : CII·O T Chan, L X Yang
Mar 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L N HarrisR C Bentley
Sep 15, 2001·British Journal of Cancer·I Ray-CoquardUNKNOWN ELYPSE Study Group
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Allan LiptonJ Allard
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francisco J EstevaGabriel N Hortobagyi
Oct 17, 2003·British Journal of Cancer·S Della BellaM L Villa
Dec 18, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L V BeerepootE E Voest
Jun 9, 2004·Cancer Immunology, Immunotherapy : CII·Iuliana CarasAurora Salageanu
Aug 7, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yago NietoRoy B Jones
Aug 17, 2004·Immunity·Gavin P DunnRobert D Schreiber
Nov 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Guido FerlazzoChristian Münz
Dec 3, 2004·Cancer Research·Matthew C P SmithGary D Luker
May 4, 2005·Breast Cancer Research and Treatment·Michael J CampbellLaura J Esserman
Oct 11, 2005·Cancer Treatment and Research·Michael CampoliAugusto C Ochoa
Dec 16, 2005·Neoplasia : an International Journal for Oncology Research·Alberto Pinzon-CharryJosé Alejandro López
Aug 8, 2006·British Journal of Haematology·Mustaqeem SiddiquiLuis F Porrata
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Joanna W Y HoRonnie T P Poon
Oct 13, 2007·Science·Laura D WoodBert Vogelstein
Nov 1, 2007·Breast Cancer Research and Treatment·Christiane Richter-EhrensteinGilbert Schönfelder
Nov 29, 2007·Breast Cancer Research and Treatment·Rakhi P NaikLinda T Vahdat
Jan 12, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V LudoviniL Crinò
Jan 14, 2009·Scandinavian Journal of Clinical and Laboratory Investigation·S MariucciM Danova
Mar 18, 2009·Nursing Research·Duck-Hee KangJohn Carpenter
Feb 19, 2010·Trends in Molecular Medicine·Gwendal Lazennec, Ann Richmond
Feb 24, 2010·Microvascular Research·Patrizia Mancuso, Francesco Bertolini
Dec 17, 2010·Clinical and Experimental Medicine·Sara MariucciMarco Danova
Apr 14, 2011·Experimental Biology and Medicine·Caroline Jochems, Jeffrey Schlom

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.