Simultaneous detection of IFN-gamma and IL-4 in lesional tissues and whole unstimulated saliva from patients with oral lichen planus

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Xiao-an TaoBin Cheng

Abstract

Although the roles of interferon (IFN)-gamma and interleukin (IL)-4 in oral lichen planus (OLP) have been described extensively in past decades, the available results are controversial. Moreover, few studies have utilized simultaneous detection of cytokines in local tissues and saliva to determine whether salivary cytokines could reflect the fact of local lesions. IFN-gamma and IL-4 were determined simultaneously in lesions and whole unstimulated saliva (WUS) from OLP patients with various clinical forms. In OLP lesions, both IFN-gamma and IL-4 in erythematous/ulcerated OLP were higher significantly than that in control specimens. In WUS, however, only IFN-gamma of erythematous/ulcerated OLP was increased compared with control. Remarkably, IFN-gamma and IL-4 in WUS showed a more significant correlation to those in local tissues of all subjects. These results indicate that both IFN-gamma and IL-4 may play more important role in pathogenesis of erythematous/ulcerated OLP, and changes of these proinflammatory cytokines in WUS may reflect the status of the OLP lesion.

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Citations

Jul 5, 2013·Microbial Pathogenesis·Jian-ru WuHong-xiong Guo
Oct 26, 2013·International Journal of Oral Science·Wen-Zhao LiuQian-Ming Chen
Aug 21, 2013·Journal of the American Academy of Dermatology·Xinhua LiKaiming Zhang
Jan 12, 2017·Brazilian Oral Research·Milad AlikhaniAliasghar Naderi
Jun 3, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·C XiongG Zhou
Jul 21, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Pornpan Youngnak-PiboonratanakitMiyuki Azuma
Mar 21, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Xiao-An TaoBin Cheng
Dec 15, 2015·Periodontology 2000·Yazan Hassona, Crispian Scully
Nov 14, 2012·International Journal of Epidemiology·Rashida PramanikGordon B Proctor
Dec 18, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Rui LuGang Zhou
Sep 27, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chenyan JiangGuoyao Tang
Aug 16, 2018·Brazilian Oral Research·Janaina Silva Martins HumbertoAna Carolina Fragoso Motta
Mar 12, 2021·Clinical Oral Investigations·Svetlana TarasenkoAlexey Unkovskiy

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