Simultaneous detection of residues of 25 β₂-agonists and 23 β-blockers in animal foods by high-performance liquid chromatography coupled with linear ion trap mass spectrometry

Journal of Agricultural and Food Chemistry
Fan SaiWu Yongning

Abstract

A sensitive method has been developed for the simultaneous determination of residues of 25 β₂-agonists and 23 β-blockers in animal foods by high-performance liquid chromatography coupled with linear ion trap mass spectrometry (HPLC-LIT-MS). This method is based on a new procedure of hydrolysis and extraction by 5% trichloracetic acid, and then cleaned up by mixed strong cation exchange (MCX) cartridges coupled with a novelty cleanup step by methanol. Methanol and 0.1% formic acid were used as mobile phases for gradient elution, while a Supelco Ascentis Express Rp-Amide column was used for LC separation. ESI positive ion scan mode was used with consecutive reaction monitoring (CRM, MS³). Nine β₂-agonists labeled by the deuterium isotope were used as internal standards for quantification. The linear ranges of 48 analytes were from 5 to 200 μg/L; the coefficient of correlation was not less than 0.995. Blank pork muscle, blank liver, and blank kidney were selected as representative matrix for spiked standard recovery test. The recoveries of each compound were in the range of 46.6-118.9%, and the relative standard deviations were in the range of 1.9-28.2%. Decision limits (CCα, α = 0.01) of 48 analytes in muscles, liver, and kidney ...Continue Reading

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Citations

Aug 22, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Gui-Jun ZhangLi-Min He
Nov 22, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Lenise Guimarães de OliveiraFábio Ferreira Gonçalves
Dec 14, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Patricia RegalAlberto Cepeda
Apr 30, 2017·Journal of Agricultural and Food Chemistry·Ying-Heng ChenLing-Wei Hsin
Jul 17, 2015·Luminescence : the Journal of Biological and Chemical Luminescence·Shuyun BiHuifeng Zhou
Jul 21, 2020·Critical Reviews in Analytical Chemistry·Sercan YıldırımBengi Uslu
Sep 14, 2013·Luminescence : the Journal of Biological and Chemical Luminescence·Qin Wang, Shengrui Zhang
Oct 19, 2016·Journal of Labelled Compounds & Radiopharmaceuticals·Kai SunYi Xu
May 28, 2021·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Anton KaufmannStephan Walker

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