Simultaneous determination of 38 veterinary antibiotic residues in raw milk by UPLC-MS/MS

Food Chemistry
R W HanJing Wang

Abstract

A selective and rapid method has been developed to determine, simultaneously, 38 veterinary antibiotic residues in raw milk by ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). One milliliter of raw milk was diluted with 0.5 mL water and 3 mL acetonitrile, then purified using an Oasis HLB cartridge. The eluates were evaporated by nitrogen drying and then reconstituted to 4 mL with water/acetonitrile (8:1) before being injected into the UPLC-MS/MS system. The results indicated recoveries of 68-118% for 14 β-lactams, 79-118% for eight quinolones, 71-106% for eight sulfonamides, 76-116% for four tetracyclines, 78-106% for three macrolides, and 88-103% for one lincosamides, with coefficients of variation less than 15% for intraday and interday precisions. The limit of quantification for all antibiotics was 0.03-10 μg kg(-1). This methodology was then applied to field-collected real raw milk samples and trace levels of four antibiotics were detected.

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Citations

May 18, 2016·Journal of Hazardous Materials·Jiu-Qiang XiongByong-Hun Jeon
Jun 4, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Meixia ChenJiaqi Wang
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Mar 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lin PanBilige Menghe
Aug 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yao FengZhao-Jun Li
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Jun 15, 2019·Journal of Agricultural and Food Chemistry·Jun ChenWen-Jing Deng

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