Simultaneous determination of antiviral drugs in chicken tissues by ultra high performance liquid chromatography with tandem mass spectrometry

Journal of Separation Science
Zhengcai LiuZhijiao Su

Abstract

An ultra high performance liquid chromatography with tandem mass spectrometry method was established for the rapid and simultaneous analysis of seven antiviral drugs, amantadine, rimantadine, memantine, moroxydine, imiquimod, oseltamivir, and acyclovir, in chicken liver, muscle, and egg. Homogenized samples were extracted with trichloroacetic acid and acetonitrile solutions and then purified by cation-exchange solid-phase extraction. The target drugs were analyzed by liquid chromatography with a UPLC BEH Amide column (2.1 mm × 100 mm, 1.7 μm) coupled with a tandem mass spectrometer operating in the positive multiple-reaction mode. A perfectly linear relationship was obtained within the concentration ranges of 0.5-20 μg/L for acyclovir and 0.1-10 μg/L for the other six antiviral drugs. The average recoveries of the seven antiviral drugs using four addition levels in chicken liver, muscle, and eggs were 82.67-90.10, 82.30-92.27, and 81.98-93.77%, respectively, and the acceptable coefficients of variation were 5.18-9.88, 4.84-11.2, and 42.8-9.95%, respectively. The detection limits and detection capabilities of the analysis method for the seven antiviral drugs were in the ranges of 0.04-0.64 and 0.11-0.78 μg/kg, respectively. Addi...Continue Reading

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Citations

Apr 5, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Didem Giray Dilgin, Serkan Karakaya
Jan 21, 2017·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yumi TsuruokaTetsuya Shindo
Sep 14, 2018·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Jian LiNengsheng Ye
May 14, 2021·Critical Reviews in Analytical Chemistry·Ozge SelcukBengi Uslu

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