Simultaneous determination of bisphenol A and estrogens in hair samples by liquid chromatography-electrospray tandem mass spectrometry

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Chaelin LeeSung-Hee Cho

Abstract

Bisphenol A (BPA), an endocrine disrupter, is widely used to make chemicals for polycarbonate, plastics, beverage containers, epoxy resins, and cash register receipts. BPA is one of the known xenoestrogens, which have weak estrogenic activity and cause obesity, diabetes, breast cancer, and reproductive disorders. Even though the concentration level of metabolomes in hair is usually lower than that in urine and blood, there are several reasons why we chose to use hair samples. First, the sampling procedure of hairs is simple. Second, it is also easy to preserve the sample for long term and track the drug-exposure record of a given sample. Third, deformation and contamination of samples rarely occur. In this study, an improved analytical method to determine the levels of BPA and estrogens in hair samples was developed by liquid chromatography-electrospray tandem mass spectrometry (LC-ESI/MS/MS). Hair samples were extracted by an Oasis HLB extraction cartridge after incubation with 1N HCl and derivatized with dansyl chloride to increase sensitivity. BPA and estrogens (estrone, 17β-estradiol, and estriol) were separated using Shiseido CAPCELL PAK C18 column (2.0×100mm, 3μm) and a mobile phase consisting of 10mM ammonium acetate in ...Continue Reading

Citations

May 4, 2018·Journal of Applied Toxicology : JAT·Vasiliki KarziAristidis M Tsatsakis
Oct 6, 2018·Rapid Communications in Mass Spectrometry : RCM·Sung-Hee Cho, Han-Na Song
Dec 8, 2019·The Science of the Total Environment·Ioanna KatsikantamiAristidis M Tsatsakis
Oct 21, 2017·Biochemical and Biophysical Research Communications·Sohrab KazemiAli Akbar Moghadamnia
Jun 3, 2021·International Journal of Molecular Sciences·Marcela Valko-RokytovskáZuzana Kostecká
Apr 22, 2019·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sângela Nascimento do CarmoEduardo Carasek
Jun 22, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ruiguo WangXiaoou Su
Oct 16, 2021·Analytical and Bioanalytical Chemistry·Iran Ocaña-RiosKingsley K Donkor

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