Simultaneous determination of p-aminobenzoic acid, acetyl-p-aminobenzoic acid and p-aminohippuric acid in serum and urine by capillary gas chromatography with use of a nitrogen-phosphorus detector

Clinica Chimica Acta; International Journal of Clinical Chemistry
J C LibeerP J Schepens

Abstract

In various studies during recent years, the use of p-aminobenzoic acid has been described in screening tests for exocrine pancreatic function. A synthetic three-unit compound N-benzoyl-L-tyrosyl-p-aminobenzoic acid has been administered orally and hydrolysed in the small intestine in the presence of chymotrypsin to N-benzoyl-L-tyrosine and p-aminobenzoic acid. This study describes a convenient procedure in which, after a selective extraction and derivatization with diazomethane, capillary gas chromatography is used combined with nitrogen-sensitive detection. With the proposed procedure, p-aminobenzoic acid and its major metabolites, acetyl-p-aminobenzoic acid and p-aminohippuric acid, can be monitored in serum and in urine samples.

References

Aug 1, 1978·Archives of Disease in Childhood·M SacherD H Shmerling
Sep 24, 1976·Deutsche medizinische Wochenschrift·G A StalderK Gyr
Feb 16, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·W BornscheinM Otte
Sep 1, 1980·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·C LangF Arenz

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Citations

Jul 1, 1994·Annals of Clinical Biochemistry·N Lawson, I Chesner
Jan 1, 1984·Journal of Pharmaceutical and Biomedical Analysis·A Hulshoff, H Lingeman
Oct 10, 2021·Digestive Diseases and Sciences·Yoshihiro SakanoHidetoshi Eguchi

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