Simultaneous Determination of Pharmaceuticals by Solid-phase Extraction and Liquid Chromatography-Tandem Mass Spectrometry: A Case Study from Sharjah Sewage Treatment Plant

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Mohammad H SemreenKumud Acharya

Abstract

The present work describes the optimization and validation of a highly selective and sensitive analytical method using solid phase extraction and liquid chromatography tandem mass spectrometry (SPE LC-MS/MS) for the determination of some frequently prescribed pharmaceuticals in urban wastewater received and treated by Sharjah sewage treatment plant (STP). The extraction efficiency of different SPE cartridges was tested and the simultaneous extraction of pharmaceuticals was successfully accomplished using hydrophilic-lipophilic-balanced reversed phase Waters® Oasis HLB cartridge (200 mg/ 6 mL) at pH 3. The analytes were separated on an Aquity BEH C18 column (1.7 µm, 2.1 mm × 150 mm) using gradient elution and mass spectrometric analysis were performed in multiple reactions monitoring (MRM) selecting two precursor ions to produce ion transition for each pharmaceutical using positive electrospray ionization (+ESI) mode. The correlation coefficient values in the linear calibration plot for each target compound exceeded 0.99 and the recovery percentages of the investigated pharmaceuticals were more than 84%. Limit of detection (LOD) varied between 0.1⁻1.5 ng/L and limit of quantification (LOQ) was 0.3⁻5 ng/L for all analytes. The pr...Continue Reading

References

Feb 3, 2005·Environmental Toxicology and Chemistry·Paul M Thomas, Gregory D Foster
Sep 4, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jochen K SchubertRalf G Mundkowski
Nov 26, 2011·Environmental Science and Pollution Research International·Athanasios S StasinakisNikolaos S Thomaidis
May 1, 2012·Environmental Science and Pollution Research International·Pablo Vazquez-RoigYolanda Picó
Jun 1, 2012·Environmental Health Perspectives·Alistair B A BoxallGlen Van Der Kraak
Aug 13, 2013·The Science of the Total Environment·Christina I KosmaTriantafyllos A Albanis
Aug 30, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Julia RossmannWilhelm Kirch
Oct 1, 2017·The Science of the Total Environment·José Abraham Rivera-JaimesMiren López de Alda

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Citations

Jan 24, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Julia Machado KhouryFrederico Duarte Garcia
Nov 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuanman LiuXuesheng Wang
Mar 9, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Saranya GopalakrishnanS Pushpavanam
Nov 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniele Sadutto, Yolanda Picó

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