Simultaneous determination of potassium and total fluoride in toothpastes using a SIA system with two potentiometric detectors

Journal of Pharmaceutical and Biomedical Analysis
R Pérez-OlmosI Díez

Abstract

A sequential injection analysis (SIA) system has been developed for the first time to quantify potassium and total fluoride in toothpastes and gels used to prevent both dentinal hypersensitivity and dental caries. To enable this simultaneous determination, potentiometric detection, using a conventional fluoride electrode and a tubular potassium selective electrode, formed by a PVC membrane containing valinomycin as ionophore, was carried out. A manifold that uses a three-way solenoid valve was designed. The former under binary sampling conditions, provides reproducible mixing ratios of two solutions. This fact facilitates that the system automatically generates, on-line, the calibration curves required by the analytical procedure. The calibration ranged from 1.0 x 10(-4) to 1.0 x 10(-3) mol L(-1) for both potassium and total fluoride determinations. The R.S.D. (11 readings) resulted to be less than 1.5% for both determinations. Off-line studies related to the dissolution of the solid samples, the transformation of monofluorophosphate in fluoride, the elimination of organic matrix interference onto the plastic membrane of the potassium electrode, and the selection of the most adequate TISAB solution for fluoride determination, w...Continue Reading

Citations

Mar 16, 2013·Journal of Periodontology·Giovanna OrsiniAngelo Putignano
Oct 16, 2015·Critical Reviews in Analytical Chemistry·Hossein YahyaviMajid Mirmoghaddam
Nov 5, 2014·The Analyst·Miriam Más-MontoyaAlberto Tárraga

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