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Simultaneous determination of propranolol and 4-hydroxypropranolol in plasma by mass fragmentography

Journal of Chromatography

Nov 26, 1975

Timo K WalleEberhard Conradi

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Abstract

A quantitative method for the simultaneous determination of propranolol and its active metabolite 4-hydroxypropranolol in human plasma is described. Plasma samples are extracted at pH 9.6 with ethyl acetate after the addition of sodium bisulphite and the internal standard oxprenolol. Th...read more

Mentioned in this Paper

Plasma
Gas Chromatography-Mass Spectrometry
Prescribed
Propranolol
Sodium bisulfite
Detection
Trifluoroacetic anhydride
Determination Aspects
Study, Methodological
Chromatography, Gas-Liquid-Mass Spectrometry
Paper Details
References
  • References2
  • Citations21
123

Simultaneous determination of propranolol and 4-hydroxypropranolol in plasma by mass fragmentography

Journal of Chromatography

Nov 26, 1975

Timo K WalleEberhard Conradi

PMID: 417

DOI: 10.1016/s0021-9673(01)92000-x

Abstract

A quantitative method for the simultaneous determination of propranolol and its active metabolite 4-hydroxypropranolol in human plasma is described. Plasma samples are extracted at pH 9.6 with ethyl acetate after the addition of sodium bisulphite and the internal standard oxprenolol. Th...read more

Mentioned in this Paper

Plasma
Gas Chromatography-Mass Spectrometry
Prescribed
Propranolol
Sodium bisulfite

Related Papers

Paper Details
References
  • References2
  • Citations21
123

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