Simultaneous determination of quinine and four metabolites in plasma and urine by high-performance liquid chromatography

Journal of Chromatography. B, Biomedical Sciences and Applications
R A MirghaniL L Gustafsson

Abstract

The determination of quinine, (3S)-3-hydroxyquinine, 2'-quininone and (10R)- and (10S)-10,11-dihydroxydihydroquinine in plasma and urine samples is described. This is the first time the R and S configurations have been correctly assigned to the two metabolites of 10,11-dihydroxyquinine. One hundred microliter-plasma samples were protein precipitated with 200 microl cold methanol. Urine samples were 10-100 x diluted and then directly injected into the HPLC. A reversed-phase liquid chromatography system with fluorescence detection and a Zorbax Eclipse XDB phenyl column and gradient elution was used. The within and between assay coefficients of variation of the method for quinine and its metabolites in plasma and urine was less than 13%. The lower limit of quantitation was in the range of 0.024-0.081 microM.

References

Apr 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·O O BolajiP A Dixon
Jul 8, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·R A MirghaniL L Gustafsson
Oct 29, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·P BannonJ P Villeneuve

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Citations

Jul 24, 2010·Analytical and Bioanalytical Chemistry·Daniel M Müller, Katharina M Rentsch
Jul 14, 2011·Pharmacogenetics and Genomics·Nilufer RahmiogluKourosh R Ahmadi
Mar 21, 2009·The Journal of Pharmacy and Pharmacology·Julius O SoyinkaJames M Cook
Jan 18, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·H IbrahimF Couderc
Jun 1, 2005·Luminescence : the Journal of Biological and Chemical Luminescence·Guofeng TangWenbing Shi
Feb 9, 2007·Journal of Clinical Pharmacy and Therapeutics·I I AbdelrahimR A Mirghani
Apr 2, 2015·Critical Reviews in Analytical Chemistry·Mariusz KluskaWiesław Prukała
Sep 21, 2005·Biochemical and Biophysical Research Communications·Cristina Rodríguez-AntonaMagnus Ingelman-Sundberg
Jan 16, 2009·Basic & Clinical Pharmacology & Toxicology·Henrik GréenCurt Peterson
Mar 18, 2010·British Journal of Clinical Pharmacology·Julius O SoyinkaJames M Cook
Jun 10, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Monica Escolà CasasErland Björklund
Apr 2, 2010·Therapeutic Drug Monitoring·Jackson K MukonzoEleni Aklillu
May 14, 2003·European Journal of Clinical Pharmacology·Rajaa A MirghaniLeif Bertilsson
Nov 9, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Martin N FranssonLena E Friberg
Apr 5, 2019·British Journal of Clinical Pharmacology·Anna SvedbergHenrik Gréen
Nov 16, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Rajaa A MirghaniOrjan Ericsson
Apr 16, 2011·Journal of Proteome Research·Nilufer RahmiogluE Kate Kemsley

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