Simultaneous determination of sweeteners in beverages by LC-MS/MS

Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Hiroaki SakaiNaoki Mochizuki

Abstract

A new method was established for the simultaneous determination of 10 sweeteners and a degradation product in beverages by using LC-MS/MS. An ACQUITY UPLC BEH C18 (2.1 × 100 mm, 1.7 μm) was used as the LC column and 0.1% each of aqueous formic acid and formic acid in acetonitrile were used as the mobile phase. A simple and rapid determination of sweeteners was possible by diluting with a solvent, and in the case of some samples containing a large amount of foreign matter, after pre-treatment by diluting with solvent and clean-up of the sample using an Oasis HLB cartridge. All the validation results were satisfactory. As the regulations and standards for sweeteners vary from country to country, a field survey of 58 beverages marketed in Japan was performed using the present method. No issues concerning the labelling or food sanitation law were found in the tested samples.

References

Nov 1, 1951·Journal of the American Pharmaceutical Association·O G FITZHUGHJ P FRAWLEY
Jul 27, 2005·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Masamichi KoyamaTamami Sasaki
Mar 12, 2009·Journal of Agricultural and Food Chemistry·Da-jin Yang, Bo Chen
Jul 19, 2013·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Sayuri TsurudaKouichi Akaki

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Citations

Apr 12, 2017·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·B SargaçoE Vasco
Sep 11, 2020·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Miguel BasílioCeleste M Lino
Jul 1, 2020·Nutrients·Kimber van VlietM Rebecca Heiner-Fokkema

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