Simultaneous determination of ten neonicotinoid insecticides and two metabolites in honey and Royal-jelly by solid-phase extraction and liquid chromatography-tandem mass spectrometry

Food Chemistry
Jianbo HouChao Han

Abstract

An analytical method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the first simultaneous determination of ten neonicotinoid insecticides (pymetrozine, dinotefuran, nitenpyram, thiamethoxam, flonicamid, imidacloprid, clothianidin, imidaclothiz, acetamiprid, thiacloprid) and two metabolites (4-trifluoromethylnicotinamide and N-desmethylacetamiprid) in honey and royal-jelly. The quantitative detection was performed by LC-MS/MS on multiple reaction monitoring (MRM) mode under positive-ion electrospray ionization. The isotope dilution internal standard method or external standard method was used for quantitation analysis. The limits of quantification (LOQs), calculated as 10 times the standard deviation, were 0.25-5.0 µg kg-1 for ten neonicotinoid insecticides and two metabolites. The average recoveries were in the range of 72.8-106.5%, with relative standard deviations (RSDs) below 13.8%, measured at three concentration levels. The developed method exhibits a high sensitivity and suitable for the simultaneous determination of neonicotinoid insecticides and metabolites in honey and royal-jelly.

Citations

Dec 12, 2019·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Oya Yeter, Adnan Aydın
Feb 20, 2020·Critical Reviews in Analytical Chemistry·Xijuan Tu, Wenbin Chen
Aug 26, 2020·Journal of Separation Science·Laura Carbonell-RozasAna M García-Campaña
Aug 2, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wenbin ChenXijuan Tu
Apr 3, 2020·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Shijia GeDeyu Hu
Oct 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mingming HanZhimin Zhang
Feb 3, 2021·Environmental Science and Pollution Research International·Saorla KavanaghBlánaid White
Dec 29, 2020·Journal of the Science of Food and Agriculture·Huan YuLi Zhou
Feb 11, 2021·Nutrients·Nicolas CollazoMiguel A Prieto
Jan 29, 2021·Water Science and Technology : a Journal of the International Association on Water Pollution Research·Qi ChenJianzhong Zhu

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