PMID: 2488637Jan 1, 1989Paper

Simultaneous determination of the two components of picrotoxin in serum by reversed-phase high-performance liquid chromatography with application to a pharmacokinetic study in rats

Journal of Pharmaceutical and Biomedical Analysis
R Soto-OteroG Sierra-Marcuño

Abstract

A reversed-phase HPLC method is reported which allows the quantification of picrotin and picrotoxinin in serum. A linear response was obtained for both drugs in the range 0.2-20 micrograms ml-1. The within-day and between-day precisions were 0.8-3.7% and 1.3-4.9%, respectively. The mean recoveries were greater than 94.2%. The method was applied to a pharmacokinetic study following intraperitoneal (i.p.) administration of 3 mg kg-1 of picrotoxin in rats. The obtained data suggest a relatively slow absorption after i.p. administration followed by a rapid elimination from the central compartment according to a one-compartment open model. The elimination half-lives were 0.340 +/- 0.0308 h for picrotin and 0.312 +/- 0.0241 h for picrotoxinin.

References

Aug 1, 1978·Computers and Biomedical Research, an International Journal·C Gomeni, R Gomeni
Jul 1, 1968·Journal of Medicinal Chemistry·C H JarboeR T Buckler

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Citations

Jun 1, 1994·Respiration Physiology·M PokorskiM Szereda-Przestaszewska
Jul 28, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·J RossiA F Nordholm
Nov 21, 2008·Journal of Food Science·J E Jablonski, L S Jackson
Oct 2, 2012·Toxicology and Applied Pharmacology·Michael P ShakarjianLibor Velíšek
Jul 8, 2016·Annals of the New York Academy of Sciences·Michael P ShakarjianLibor Velíšek
May 16, 2021·Animal Reproduction Science·Daniel CardosoGuilherme de Paula Nogueira

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