Simultaneous Determination of Type A and B Trichothecenes and Their Main Metabolites in Food Animal Tissues by Ultraperformance Liquid Chromatography Coupled with Triple-Quadrupole Mass Spectrometry

Journal of Agricultural and Food Chemistry
Shupeng YangZhanhui Wang

Abstract

A rapid method for the liquid chromatography-tandem mass spectrometric determination of type A and B trichothecenes and their major metabolites in chicken meat, pork, chicken liver, and swine liver was developed. The analytes included T-2 toxin, HT-2 toxin, T-2 triol, neosolaniol, deoxynivalenol, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, deepoxydeoxynivalenol, and nivalenol. The compounds were extracted from samples with acetonitrile/ethyl acetate (1:3, v/v) and then cleaned up using Oasis HLB cartridges. Analysis was carried out with ultraperformance liquid chromatography-tandem mass spectrometry. The mean recoveries of spiked samples ranged from 74.1% to 96.9% with intraday and interday relative standard deviations of less than 9.9% and 9.1%, respectively. The limit of detection and limit of quantitation ranged from 3.0 to 15.0 μg/kg and from 10.0 to 50.0 μg/kg, respectively. The proposed method has been successfully applied for analysis of real samples, with the primary results indicating that, compared to mycotoxins themselves, their metabolites are more likely to occur and be detectable in animal tissue foods.

References

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Sep 30, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·N BroekaertS Croubels

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Citations

Aug 19, 2017·Toxins·Laura EscriváHouda Berrada
Apr 19, 2017·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Jan Alexander
Sep 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Arnau VidalMarthe De Boevre
Jul 13, 2018·Journal of Agricultural and Food Chemistry·Shupeng YangFeifei Sun

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