Simultaneous development of Kawasaki disease following acute human adenovirus infection in monozygotic twins: A case report

Pediatric Rheumatology Online Journal
Sayaka FukudaHiroshi Katsumori

Abstract

The etiology of Kawasaki disease (KD) remains unknown. However, many studies have suggested that specific genetic factors and/or some infectious agents underlie the onset of KD. Previous studies have suggested that human adenovirus (HAdV) is one of the triggering pathogens of KD. Here, we report monozygotic twin boys who sequentially developed KD in conjunction with acute HAdV type 3 (HAdV-3) infection. The patients were four-year-old monozygotic twin boys. The elder brother developed a high fever and was diagnosed with HAdV infection with an immunochromatographic kit for HAdV (IC-kit). He was transferred to our institute after persistent fever for 7 days. On admission, he already fulfilled all the diagnostic criteria for KD. His laboratory data were as follows: WBC, 9700/μl; CRP, 2.42 mg/dl; IFN-γ, 99.8 pg/ml; and TNF-α, 10.9 pg/ml. He received intravenous immunoglobulin (IVIG) and aspirin and responded well, with no coronary artery abnormalities. The younger brother, who was also IC-kit-positive, was hospitalized on the same day as his elder brother after persistent fever for 3 days. His data on admission were as follows: WBC, 12,600/μl; CRP, 5.54 mg/dl; IFN-γ, 105.0 pg/ml; and TNF-α, 33.6 pg/ml. Although he developed all of ...Continue Reading

References

Apr 27, 2000·The Pediatric Infectious Disease Journal·T W KuijpersE M Van De Veer
Dec 13, 2006·Journal of Human Genetics·Yoshihiro OnouchiAkira Hata
Apr 29, 2010·Human Molecular Genetics·Yoshihiro OnouchiToshihiro Tanaka
Jul 29, 2011·The Pediatric Infectious Disease Journal·Aubri KottekJane C Burns
Sep 27, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Preeti JaggiAmy Leber
Feb 6, 2014·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Luan-Yin ChangLi-Min Huang

❮ Previous
Next ❯

Citations

Jan 26, 2018·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Ryoko NariaiAkira Ishiguro
Jan 29, 2020·Journal of the Chinese Medical Association : JCMA·Shih-Hui HuangJames Cheng-Chung Wei
Aug 11, 2020·Clinical Rheumatology·Aaqib Zaffar BandaySurjit Singh
Nov 14, 2017·International Journal of Rheumatic Diseases·Surjit SinghRakesh Kumar Pilania
Feb 20, 2018·World Journal of Clinical Pediatrics·Rakesh Kumar PilaniaSurjit Singh
Apr 27, 2021·The Pediatric Infectious Disease Journal·Kanako HayashidaYosikazu Nakamura
Jun 27, 2021·Scientific Reports·Sayaka FukudaUNKNOWN Japan Environment and Children’s Study (JECS) Group

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

© 2022 Meta ULC. All rights reserved