Simultaneous editing of GABA and GSH with Hadamard-encoded MR spectroscopic imaging.

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Kimberly L ChanPeter B Barker

Abstract

To evaluate the feasibility of simultaneous MR spectroscopic imaging (MRSI) of gamma-aminobutyric acid (GABA) and glutathione (GSH) in the human brain using Hadamard Encoding and Reconstruction of MEGA-Edited Spectroscopy (HERMES). Point RESolved Spectroscopy (PRESS)-localized MRSI was performed in GABA and GSH phantoms and in the human brain (n = 3) using HERMES editing and compared to conventional MEGA editing of each metabolite. Multiplet patterns, signal intensities, and metabolite crosstalk were compared between methods. GABA+ and GSH levels were compared between methods for bias and variability. Linear regression of HERMES-MRSI GABA+/H2 O and GSH/H2 O versus gray matter (GM) fraction were performed to assess differences between GM and white matter (WM). Phantom HERMES-MRSI scans gave comparable GABA+ and GSH signals to MEGA-MRSI across the PRESS-localized volume. In vivo, HERMES-reconstructed GABA+ and GSH values had minimal measurement bias and variability relative to MEGA-MRSI. Intersubject coefficients of variation (CV) from two regions within the PRESS-localized volume for HERMES and MEGA were 6-12% for GABA+ and 6-19% for GSH. Interregion CVs were 5-15% for GABA+ and 3-17% for GSH. The GABA+/H2 O and GSH/H2 O ratios ...Continue Reading

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Citations

Apr 18, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Muhammad G SalehThomas Ernst
Jul 30, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lihong TangJie Luo
Sep 19, 2020·NMR in Biomedicine·In-Young ChoiRobin A de Graaf
Jan 22, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yury KoushFahmeed Hyder
Jul 20, 2021·NeuroImage. Clinical·Tao GongGuangbin Wang
Oct 8, 2021·Molecular Autism·Laurie-Anne Sapey-TriompheJohan Wagemans
Dec 22, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Masoumeh DehghaniJamie Near
Jan 27, 2022·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yury KoushFahmeed Hyder

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