Simultaneous enantioselective determination of isocarbophos and its main metabolite isocarbophos oxon in rice, soil, and water by chiral liquid chromatography and tandem mass spectrometry

Journal of Separation Science
Zhoulin YaoHu Zhang

Abstract

An efficient enantioselective method for the simultaneous determination of isocarbophos and its main metabolite isocarbophos oxon in rice, soil, and water was developed using liquid chromatography with tandem mass spectrometry. The enantioseparation was performed on a Chiralpak AD-3R column at 30°C using gradient elution. Target compounds were extracted from soil and rice using acetonitrile with omission of a clean-up procedure, while a C18 solid-phase extraction column was used for water samples. Quantification was achieved using matrix-matched calibration. The overall mean recoveries for isocarbophos and isocarbophos oxon enantiomers from the five matrices were 89.7-103 and 90.1-98.7%, with relative standard deviations of 2.1-5.4 and 2.5-4.7%, respectively. Moreover, the absolute configurations of isocarbophos oxon enantiomers were determined by liquid chromatography with tandem mass spectrometry through incubation of each isocarbophos enantiomer in soil, the first eluting enantiomer being confirmed as (R)-(-)-isocarbophos oxon. The proposed method was applied to real soil samples and satisfactory results were obtained.

References

Jul 5, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Wolfgang BickerWolfgang Lindner
May 23, 2006·Analytical and Bioanalytical Chemistry·Charles S Wong
May 19, 2007·Bulletin of Environmental Contamination and Toxicology·Z Y LiL Leng
Jan 18, 2008·Chirality·Stig Allenmark, Jacek Gawronski
May 21, 2008·Journal of Agricultural and Food Chemistry·Kunde LinJay Gan
Dec 8, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Mae Grace NillosDaniel Schlenk
Apr 26, 2012·Journal of Separation Science·Hu ZhangMinghua Wang
Feb 18, 2014·Journal of Separation Science·Gerardo Martínez-DomínguezAntonia Garrido Frenich
Apr 23, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xiao-Mei ZhuangHua Li

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Citations

May 2, 2018·Environmental Science and Pollution Research International·Lidong WangXinquan Wang
Sep 15, 2020·Frontiers in Chemistry·Huixiang OuyangZhiliang Jiang
Nov 10, 2018·Journal of Hazardous Materials·Hui LiuZhiqiang Zhou

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